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    CEACAM20 CEA cell adhesion molecule 20 [ Homo sapiens (human) ]

    Gene ID: 125931, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CEACAM20provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 20provided by HGNC
    Primary source
    HGNC:HGNC:24879
    See related
    Ensembl:ENSG00000273777 AllianceGenome:HGNC:24879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ9366
    Summary
    Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in regulation of immune system process and signal transduction. Predicted to be located in apical plasma membrane and microvillus membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine (RPKM 13.3), duodenum (RPKM 12.5) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See CEACAM20 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44506159..44529675, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47331670..47355129, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45010211..45033698, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 285B, pseudogene Neighboring gene MPRA-validated peak3500 silencer Neighboring gene zinc finger protein 180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45003842-45004342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45004343-45004843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14763 Neighboring gene CEA cell adhesion molecule 22, pseudogene Neighboring gene MPRA-validated peak3502 silencer Neighboring gene Sharpr-MPRA regulatory region 3461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45081555-45082086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45092773-45093272 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:45097005-45097830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45099482-45100306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45118285-45118786 Neighboring gene immunoglobulin superfamily member 23 Neighboring gene Sharpr-MPRA regulatory region 2639

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role. Daniwijaya EW, et al. Kobe J Med Sci, 2013 Mar 3. PMID 28659570
    2. Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis. Zhang H, et al. PLoS One, 2013. PMID 23358633, Free PMC Article
    3. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. Zebhauser R, et al. Genomics, 2005 Nov. PMID 16139472
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tyrosine phosphorylation of CEACAM20 likely promotes phagocytic activity
      Title: Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role.
    2. conclude that CEACAM20 and CEACAM1 not only mark the lumina of adult prostate tissue but also play a critical role in the vitro generation of prostate organoids
      Title: Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell adhesion molecule CEACAM20; carcinoembryonic antigen-related cell adhesion molecule 20
    Names
    GPAD9366
    carcinoembryonic antigen related cell adhesion molecule 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102597.3 → NP_001096067.2  cell adhesion molecule CEACAM20 isoform 5L precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5L) represents the longest transcript and encodes the longest isoform (5L).
      Source sequence(s)
      AC245748, AY358129, EU008600
      Consensus CDS
      CCDS74393.1
      UniProtKB/Swiss-Prot
      A0A087WXE1, A0A087WYH6, A0A087WYM6, A0A087WZX4, A0A087X155, A7LFK7, A7LFK8, A7LFK9, A7LFL0, Q6UY09
      Related
      ENSP00000481937.1, ENST00000614924.5
      Conserved Domains (2) summary
      pfam13927
      Location:361 → 420
      Ig_3; Immunoglobulin domain
      cl11960
      Location:266 → 343
      Ig; Immunoglobulin domain

    2. NM_001102598.3 → NP_001096068.2  cell adhesion molecule CEACAM20 isoform 4S precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4S) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 5L, resulting in an isoform (4S) that is shorter than isoform 5L.
      Source sequence(s)
      AC245748, AY358129, EU008600, EU008601
      Consensus CDS
      CCDS74390.1
      UniProtKB/Swiss-Prot
      Q6UY09
      UniProtKB/TrEMBL
      A0A087WYH6, A7LFK7, A7LFK8
      Related
      ENSP00000481812.1, ENST00000620096.4
      Conserved Domains (4) summary
      smart00410
      Location:175 → 247
      IG_like; Immunoglobulin like
      pfam13895
      Location:175 → 247
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:379 → 435
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:266 → 343
      Ig; Immunoglobulin domain

    3. NM_001102599.3 → NP_001096069.2  cell adhesion molecule CEACAM20 isoform 4L precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4L) lacks an alternate in-frame exon in the central coding region, compared to variant 5L, resulting in an isoform (4L) that is shorter than isoform 5L.
      Source sequence(s)
      AC245748, AY358129, EU008600, EU008602
      Consensus CDS
      CCDS74391.1
      UniProtKB/Swiss-Prot
      Q6UY09
      UniProtKB/TrEMBL
      A0A087WZX4, A7LFK7, A7LFK9
      Related
      ENSP00000482943.1, ENST00000614577.4
      Conserved Domains (4) summary
      smart00410
      Location:175 → 247
      IG_like; Immunoglobulin like
      pfam13895
      Location:175 → 247
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:379 → 434
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:266 → 343
      Ig; Immunoglobulin domain

    4. NM_001102600.3 → NP_001096070.2  cell adhesion molecule CEACAM20 isoform 5S precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5S) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5L, resulting in an isoform (5S) that is shorter than isoform 5L.
      Source sequence(s)
      AC245748, AY358129, EU008600, EU008603
      Consensus CDS
      CCDS74392.1
      UniProtKB/Swiss-Prot
      Q6UY09
      UniProtKB/TrEMBL
      A0A087X155, A7LFK7, A7LFL0
      Related
      ENSP00000483912.1, ENST00000611497.4
      Conserved Domains (4) summary
      smart00410
      Location:361 → 433
      IG_like; Immunoglobulin like
      pfam13895
      Location:369 → 435
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:472 → 528
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:266 → 343
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44506159..44529675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526430.3 → XP_011524732.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X2

      Conserved Domains (4) summary
      smart00410
      Location:388 → 460
      IG_like; Immunoglobulin like
      pfam13895
      Location:396 → 462
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:499 → 555
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:293 → 370
      Ig; Immunoglobulin domain

    2. XM_011526429.3 → XP_011524731.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X1

      Conserved Domains (4) summary
      smart00410
      Location:388 → 460
      IG_like; Immunoglobulin like
      pfam13895
      Location:396 → 462
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:499 → 554
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:293 → 370
      Ig; Immunoglobulin domain

    3. XM_011526432.3 → XP_011524734.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X4

      Conserved Domains (4) summary
      smart00410
      Location:107 → 179
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 181
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:218 → 273
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:12 → 89
      Ig; Immunoglobulin domain

    4. XM_011526431.3 → XP_011524733.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X3

      Conserved Domains (4) summary
      smart00410
      Location:388 → 460
      IG_like; Immunoglobulin like
      pfam13895
      Location:396 → 462
      Ig_2; Immunoglobulin domain
      pfam16821
      Location:499 → 554
      C_Hendra; C protein from hendra and measles viruses
      cl11960
      Location:293 → 370
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47331670..47355129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319740.1 → XP_054175715.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X2

    2. XM_054319739.1 → XP_054175714.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X1

    3. XM_054319742.1 → XP_054175717.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X4

    4. XM_054319741.1 → XP_054175716.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198444.1: Suppressed sequence

      Description
      NM_198444.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UY09.2 GenPept UniProtKB/Swiss-Prot:Q6UY09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials