Dnah2 dynein, axonemal, heavy chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dnah2provided by RGD
Full Name: dynein, axonemal, heavy chain 2provided by RGD
Primary source: RGD:1565087
See related: EnsemblRapid:ENSRNOG00000052688 AllianceGenome:RGD:1565087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DLP2; axo f; Dnahc2
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and inner dynein arm assembly. Predicted to be located in sperm flagellum. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium and axoneme. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 78.6), Lung (RPKM 22.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 89

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54641450..54766502, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54142648..54268901, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56029022..56154602, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium-dependent cell motility	ISO Inferred from Sequence Orthology more info
involved_in inner dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
part_of axonemal dynein complex	ISO Inferred from Sequence Orthology more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
part_of dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of inner dynein arm	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal heavy chain 2

Names: axonemal dynein heavy chain; dynein heavy chain 2, axonemal; dynein heavy chain 2, axonemal-like; dynein-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100676.1 → NP_001094146.1 dynein axonemal heavy chain 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2JYL5, Q2KML4

Related

ENSRNOP00000070702.1, ENSRNOT00000090809.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54641450..54766502 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767900.4 → XP_008766122.1 dynein axonemal heavy chain 2 isoform X1

See identical proteins and their annotated locations for XP_008766122.1

UniProtKB/TrEMBL

Q2KML4

Conserved Domains (6) summary

pfam03028
Location:3455 → 4146

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:3 → 456

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:954 → 1359

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:2737 → 3069

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3097 → 3313

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:1496 → 1726

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039087610.2 → XP_038943538.1 dynein axonemal heavy chain 2 isoform X2

UniProtKB/TrEMBL

Q2KML4

Conserved Domains (4) summary

COG5245
Location:930 → 3751

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08385
Location:2 → 360

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam12774
Location:1408 → 1734

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:3766 → 4066

Dynein_C; Dynein heavy chain C-terminal domain
XM_039087611.2 → XP_038943539.1 dynein axonemal heavy chain 2 isoform X3

Conserved Domains (3) summary

COG5245
Location:92 → 2492

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam12774
Location:149 → 475

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:2507 → 2807

Dynein_C; Dynein heavy chain C-terminal domain
XM_039087612.2 → XP_038943540.1 dynein axonemal heavy chain 2 isoform X4

Conserved Domains (5) summary

pfam08385
Location:241 → 798

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1301 → 1709

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1846 → 2172

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam17852
Location:2334 → 2430

Dynein_AAA_lid; Dynein heavy chain AAA lid domain

cl38936
Location:2162 → 2303

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases