OXSR1 oxidative stress responsive kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OXSR1provided by HGNC
Official Full Name: oxidative stress responsive kinase 1provided by HGNC
Primary source: HGNC:HGNC:8508
See related: Ensembl:ENSG00000172939 MIM:604046; AllianceGenome:HGNC:8508
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OSR1
Summary: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Annotation information: Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018]
Expression: Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.2

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (38164063..38255484)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (38170735..38261199)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (38207028..38296975)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
Title: Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
Title: Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
Title: The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
SPAK and OSR1 kinases bind and phosphorylate the beta2-Adrenergic receptor.
Title: SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.
High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
Title: High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
Regulation of ClC-2 activity by SPAK and OSR1.
Title: Regulation of ClC-2 activity by SPAK and OSR1.
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
Title: SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
Title: Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
Title: Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-86285 (e-PCR)
- UniSTS:104505

RH47460 (e-PCR)
- UniSTS:22356

D3S2887E (e-PCR)
- UniSTS:27749

T03494 (e-PCR)
- UniSTS:18289

D3S3333 (e-PCR)
- UniSTS:1933

D3S2942E (e-PCR)
- UniSTS:150925

WIAF-1617 (e-PCR)
- UniSTS:63655

SHGC-76839 (e-PCR)
- UniSTS:71883

SHGC-76846 (e-PCR)
- UniSTS:57567

SHGC-76840 (e-PCR)
- UniSTS:81897

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hypotonic response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine (C-C motif) ligand 21 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in osmosensory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in renal sodium ion absorption	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase OSR1

Names: oxidative stress responsive 1; oxidative stress-responsive 1 protein

NP_005100.1

EC 2.7.11.1

XP_011532633.1

EC 2.7.11.1

XP_016863090.1

EC 2.7.11.1

XP_024309619.1

EC 2.7.11.1

XP_024309620.1

EC 2.7.11.1

XP_047305342.1

EC 2.7.11.1

XP_047305343.1

EC 2.7.11.1

XP_047305344.1

EC 2.7.11.1

XP_054204650.1

EC 2.7.11.1

XP_054204651.1

EC 2.7.11.1

XP_054204652.1

EC 2.7.11.1

XP_054204653.1

EC 2.7.11.1

XP_054204654.1

EC 2.7.11.1

XP_054204655.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005109.3 → NP_005100.1 serine/threonine-protein kinase OSR1

See identical proteins and their annotated locations for NP_005100.1

Status: REVIEWED

Source sequence(s)

AB017642, BC008726

Consensus CDS

CCDS2675.1

UniProtKB/Swiss-Prot

O95747, Q3LR53, Q7Z501, Q9UPQ1

UniProtKB/TrEMBL

C9JIG9

Related

ENSP00000311713.3, ENST00000311806.8

Conserved Domains (2) summary

smart00220
Location:17 → 291

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06610
Location:15 → 291

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

38164063..38255484

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011534331.3 → XP_011532633.1 serine/threonine-protein kinase OSR1 isoform X1

Conserved Domains (2) summary

smart00220
Location:77 → 344

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06610
Location:77 → 344

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
XM_017007601.2 → XP_016863090.1 serine/threonine-protein kinase OSR1 isoform X2
XM_024453851.2 → XP_024309619.1 serine/threonine-protein kinase OSR1 isoform X6

Conserved Domains (1) summary

cd06610
Location:77 → 344

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
XM_047449386.1 → XP_047305342.1 serine/threonine-protein kinase OSR1 isoform X3

UniProtKB/TrEMBL

C9JIG9
XM_047449387.1 → XP_047305343.1 serine/threonine-protein kinase OSR1 isoform X4
XM_047449388.1 → XP_047305344.1 serine/threonine-protein kinase OSR1 isoform X5
XM_024453852.2 → XP_024309620.1 serine/threonine-protein kinase OSR1 isoform X7

Conserved Domains (3) summary

COG0515
Location:1 → 204

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

pfam12202
Location:242 → 273

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

cl21453
Location:1 → 99

PKc_like; Protein Kinases, catalytic domain

RNA

XR_007095781.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

38170735..38261199

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348675.1 → XP_054204650.1 serine/threonine-protein kinase OSR1 isoform X1
XM_054348676.1 → XP_054204651.1 serine/threonine-protein kinase OSR1 isoform X2
XM_054348677.1 → XP_054204652.1 serine/threonine-protein kinase OSR1 isoform X3

UniProtKB/TrEMBL

C9JIG9
XM_054348678.1 → XP_054204653.1 serine/threonine-protein kinase OSR1 isoform X4
XM_054348679.1 → XP_054204654.1 serine/threonine-protein kinase OSR1 isoform X5
XM_054348680.1 → XP_054204655.1 serine/threonine-protein kinase OSR1 isoform X7