MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [Homo sapiens (human)] - Gene

Summary

Official Symbol: MTHFD1Lprovided by HGNC
Official Full Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by HGNC
Primary source: HGNC:HGNC:21055
See related: Ensembl:ENSG00000120254 MIM:611427; AllianceGenome:HGNC:21055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FTHFSDC1; MTC1THFS; dJ292B18.2
Summary: The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Expression: Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.1

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (150865702..151101887)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (152066259..152302476)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (151186838..151423023)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma.
Title: Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma.
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers.
Title: Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers.
MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway.
Title: MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway.
Results together with the limitations of the original studies indicate that the reported associations between the MTHFD1L and FOPNL loci and MM survival are false positives due to a winner's curse effect.
Title: Sequence variation at the MTHFD1L-AKAP12 and FOPNL loci does not influence multiple myeloma survival in Sweden.
MTHFD1L protein and RNA expression levels were significantly upregulated in esophageal squamous cell carcinoma tissue as compared with normal tissue. High expression of MTHFD1 was also detected in two esophageal cancer cell lines (TE-1 and EC109).
Title: The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.
study identifies MTHFD1L in the folate cycle as an important metabolic pathway in cancer cells with the potential for therapeutic targeting
Title: Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.
Studies reported that the A allele of a polymorphism in a gene involved in folate metabolism, MTHFD1L, showed a genome-wide significant association with late-onset Alzheimer's Disease.
Title: Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression.
rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.
Title: Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome.
MTHFD1L rs6922269 genotype is associated with active vitamin B12 levels at baseline and may be a marker of prognostic risk in patients with established coronary heart disease.
Title: Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients.
Results indicate that miR-9 and MiR-197 specifically downregulate MTHFD1L in HEK293 and MCF-7 cells and that SNPrs7646 affects miR-197 binding to the MTHFD1L 3' UTR causing gene repression in the presence of the allele associated with neural tube defects.
Title: An NTD-associated polymorphism in the 3' UTR of MTHFD1L can affect disease risk by altering miRNA binding.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomewide association analysis of coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif interacts with MTHFD1L; interaction predicted to be relevant to purine pyrimidine biosynthesis	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N30148 (e-PCR)
- UniSTS:45583

RH102196 (e-PCR)
- UniSTS:96530

RH93531 (e-PCR)
- UniSTS:85541

WI-13575 (e-PCR)
- UniSTS:46641

D6S956 (e-PCR)
- UniSTS:25915

RH15823 (e-PCR)
- UniSTS:20799

RH123123 (e-PCR)
- UniSTS:135504

D2S337 (e-PCR), detects polymorphism
- UniSTS:57473

RH48516 (e-PCR)
- UniSTS:20692

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables formate-tetrahydrofolate ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables formate-tetrahydrofolate ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 10-formyltetrahydrofolate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 10-formyltetrahydrofolate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic neurocranium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic viscerocranium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in folic acid-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in formate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: monofunctional C1-tetrahydrofolate synthase, mitochondrial

Names: 10-formyl-THF synthetase; formyltetrahydrofolate synthetase domain containing 1

NP_001229696.1

EC 6.3.4.3

NP_001229697.1

EC 6.3.4.3

NP_001229698.1

EC 6.3.4.3

NP_001337415.1

EC 6.3.4.3

NP_001337416.1

EC 6.3.4.3

NP_001337417.1

EC 6.3.4.3

NP_001337418.1

EC 6.3.4.3

NP_001337419.1

EC 6.3.4.3

NP_001337420.1

EC 6.3.4.3

NP_001337421.1

EC 6.3.4.3

NP_001337422.1

EC 6.3.4.3

NP_056255.2

EC 6.3.4.3

XP_005266964.1

EC 6.3.4.3

XP_005266968.1

EC 6.3.4.3

XP_011534031.1

EC 6.3.4.3

XP_011534032.1

EC 6.3.4.3

XP_011534033.1

EC 6.3.4.3

XP_011534034.1

EC 6.3.4.3

XP_011534035.1

EC 6.3.4.3

XP_011534039.1

EC 6.3.4.3

XP_011534040.1

EC 6.3.4.3

XP_016866191.1

EC 6.3.4.3

XP_016866192.1

EC 6.3.4.3

XP_024302163.1

EC 6.3.4.3

XP_024302164.1

EC 6.3.4.3

XP_047274565.1

EC 6.3.4.3

XP_047274566.1

EC 6.3.4.3

XP_047274567.1

EC 6.3.4.3

XP_047274568.1

EC 6.3.4.3

XP_047274569.1

EC 6.3.4.3

XP_047274570.1

EC 6.3.4.3

XP_047274571.1

EC 6.3.4.3

XP_047274572.1

EC 6.3.4.3

XP_047274573.1

EC 6.3.4.3

XP_047274574.1

EC 6.3.4.3

XP_047274575.1

EC 6.3.4.3

XP_054211073.1

EC 6.3.4.3

XP_054211074.1

EC 6.3.4.3

XP_054211075.1

EC 6.3.4.3

XP_054211076.1

EC 6.3.4.3

XP_054211077.1

EC 6.3.4.3

XP_054211078.1

EC 6.3.4.3

XP_054211079.1

EC 6.3.4.3

XP_054211080.1

EC 6.3.4.3

XP_054211081.1

EC 6.3.4.3

XP_054211082.1

EC 6.3.4.3

XP_054211083.1

EC 6.3.4.3

XP_054211084.1

EC 6.3.4.3

XP_054211085.1

EC 6.3.4.3

XP_054211086.1

EC 6.3.4.3

XP_054211087.1

EC 6.3.4.3

XP_054211088.1

EC 6.3.4.3

XP_054211089.1

EC 6.3.4.3

XP_054211090.1

EC 6.3.4.3

XP_054211091.1

EC 6.3.4.3

XP_054211092.1

EC 6.3.4.3

XP_054211093.1

EC 6.3.4.3

XP_054211094.1

EC 6.3.4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029185.2 RefSeqGene

Range

5024..241209

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001242767.2 → NP_001229696.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_001229696.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC110319, BC144368, DB727926

Consensus CDS

CCDS75535.1

UniProtKB/TrEMBL

B7ZM99

Related

ENSP00000478253.1, ENST00000611279.4

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:353 → 979

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
NM_001242768.2 → NP_001229697.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK315378, BC110319, DA195967

Consensus CDS

CCDS75536.1

UniProtKB/TrEMBL

A0A087WVM4, B2RD24

Related

ENSP00000479539.1, ENST00000618312.4

Conserved Domains (4) summary

cd05212
Location:127 → 270

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:287 → 913

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:9 → 223

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:10 → 114

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
NM_001242769.3 → NP_001229698.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 4 precursor

See identical proteins and their annotated locations for NP_001229698.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks a single internal aa compared to isoform 1. Isoform 4 is thought to lack THF synthase activity.

Source sequence(s)

AW593866, AY374131, DB727926

Consensus CDS

CCDS56457.1

UniProtKB/Swiss-Prot

Q6UB35

Related

ENSP00000356276.4, ENST00000367307.8

Conserved Domains (3) summary

COG0190
Location:72 → 228

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

cl21454
Location:193 → 260

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001350486.1 → NP_001337415.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 5

Status: REVIEWED

Source sequence(s)

AL035086, AL049694, AL133260

UniProtKB/TrEMBL

B2RD24

Conserved Domains (3) summary

cd05212
Location:127 → 269

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:286 → 912

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:9 → 222

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
NM_001350487.2 → NP_001337416.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 6

Status: REVIEWED

Source sequence(s)

AL035086, AL049694, AL133260

UniProtKB/TrEMBL

B2RD24

Conserved Domains (3) summary

cd05212
Location:83 → 225

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:242 → 868

PLN02759; Formate--tetrahydrofolate ligase

pfam00763
Location:9 → 70

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
NM_001350488.3 → NP_001337417.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AL035086

Conserved Domains (2) summary

COG0190
Location:72 → 229

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cl25423
Location:193 → 261

NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
NM_001350489.3 → NP_001337418.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AL035086

Conserved Domains (1) summary

COG0190
Location:72 → 213

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
NM_001350490.1 → NP_001337419.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 9

Status: REVIEWED

Source sequence(s)

AL049694, AL133260

Conserved Domains (1) summary

pfam01268
Location:2 → 270

FTHFS; Formate--tetrahydrofolate ligase
NM_001350491.3 → NP_001337420.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 10

Status: REVIEWED

Source sequence(s)

AL035086

Conserved Domains (2) summary

COG0190
Location:9 → 119

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cl21454
Location:83 → 151

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001350492.2 → NP_001337421.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 12, encodes isoform 11.

Source sequence(s)

AL035086, AL049694, AL133260

UniProtKB/TrEMBL

B2RD24

Conserved Domains (3) summary

cd05212
Location:83 → 226

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:243 → 869

PLN02759; Formate--tetrahydrofolate ligase

pfam00763
Location:9 → 70

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
NM_001350493.1 → NP_001337422.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variant 11, encodes isoform 11.

Source sequence(s)

AL035086, AL049694, AL133260

UniProtKB/TrEMBL

B2RD24

Conserved Domains (3) summary

cd05212
Location:83 → 226

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:243 → 869

PLN02759; Formate--tetrahydrofolate ligase

pfam00763
Location:9 → 70

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
NM_015440.5 → NP_056255.2 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 2 precursor

See identical proteins and their annotated locations for NP_056255.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AY374130, BC110319, DB727926

Consensus CDS

CCDS5228.1

UniProtKB/Swiss-Prot

Q2TBF3, Q6UB35, Q8WVW0, Q96HG8, Q9H789, Q9UFU8

Related

ENSP00000356290.3, ENST00000367321.8

Conserved Domains (4) summary

cd05212
Location:193 → 335

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:352 → 978

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:72 → 288

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

RNA

NR_146719.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL035086, AL049694, AL133260
NR_146720.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL035086, AL049694, AL133260

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

150865702..151101887

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010702.3 → XP_016866191.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

UniProtKB/TrEMBL

B7ZM99

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:353 → 979

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_017010703.3 → XP_016866192.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

UniProtKB/TrEMBL

B7ZM99

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:353 → 979

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_011535729.4 → XP_011534031.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:353 → 952

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_047418610.1 → XP_047274566.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5
XM_047418609.1 → XP_047274565.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1
XM_005266907.6 → XP_005266964.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

Conserved Domains (4) summary

cd05212
Location:193 → 335

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:352 → 949

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:72 → 288

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_047418616.1 → XP_047274572.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X14
XM_047418615.1 → XP_047274571.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X13
XM_047418614.1 → XP_047274570.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X12
XM_011535737.4 → XP_011534039.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X15

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

cl21455
Location:353 → 709

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_011535738.4 → XP_011534040.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X16

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

cl21455
Location:353 → 709

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_047418617.1 → XP_047274573.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X17
XM_005266911.6 → XP_005266968.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X18

Conserved Domains (4) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:74 → 180

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

cl21455
Location:353 → 605

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_024446396.2 → XP_024302164.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X19

Conserved Domains (3) summary

cd05212
Location:193 → 336

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

COG0190
Location:72 → 289

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cl21455
Location:353 → 420

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_047418618.1 → XP_047274574.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X20
XM_011535730.2 → XP_011534032.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X8

Conserved Domains (4) summary

cd05212
Location:127 → 270

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:287 → 884

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:9 → 223

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:10 → 114

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_011535731.3 → XP_011534033.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X9

Conserved Domains (4) summary

cd05212
Location:127 → 269

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:286 → 883

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:9 → 222

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:10 → 114

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_047418613.1 → XP_047274569.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X11

UniProtKB/TrEMBL

B2RD24
XM_047418612.1 → XP_047274568.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

UniProtKB/TrEMBL

B2RD24
XM_047418611.1 → XP_047274567.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X6
XM_011535733.3 → XP_011534035.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

See identical proteins and their annotated locations for XP_011534035.1

UniProtKB/TrEMBL

B2RD24

Conserved Domains (4) summary

cd05212
Location:83 → 226

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:243 → 840

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:9 → 179

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:9 → 70

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_011535732.3 → XP_011534034.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

See identical proteins and their annotated locations for XP_011534034.1

UniProtKB/TrEMBL

B2RD24

Conserved Domains (4) summary

cd05212
Location:83 → 226

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:243 → 840

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:9 → 179

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:9 → 70

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
XM_024446395.1 → XP_024302163.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X7

Conserved Domains (3) summary

cd05212
Location:158 → 300

NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

PLN02759
Location:317 → 943

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:40 → 253

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
XM_047418619.1 → XP_047274575.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X21

Conserved Domains (1) summary

pfam01268
Location:2 → 270

FTHFS; Formate--tetrahydrofolate ligase

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

152066259..152302476

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355100.1 → XP_054211075.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

UniProtKB/TrEMBL

B7ZM99
XM_054355101.1 → XP_054211076.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4
XM_054355102.1 → XP_054211077.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5
XM_054355098.1 → XP_054211073.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1
XM_054355099.1 → XP_054211074.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2
XM_054355113.1 → XP_054211088.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X14
XM_054355112.1 → XP_054211087.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X13
XM_054355111.1 → XP_054211086.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X12
XM_054355114.1 → XP_054211089.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X15
XM_054355115.1 → XP_054211090.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X16
XM_054355116.1 → XP_054211091.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X17
XM_054355117.1 → XP_054211092.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X18
XM_054355118.1 → XP_054211093.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X19
XM_054355119.1 → XP_054211094.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X20
XM_054355105.1 → XP_054211080.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X8
XM_054355106.1 → XP_054211081.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X9
XM_054355110.1 → XP_054211085.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X11

UniProtKB/TrEMBL

B2RD24
XM_054355109.1 → XP_054211084.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

UniProtKB/TrEMBL

B2RD24
XM_054355103.1 → XP_054211078.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X6
XM_054355108.1 → XP_054211083.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

UniProtKB/TrEMBL

B2RD24
XM_054355107.1 → XP_054211082.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

UniProtKB/TrEMBL

B2RD24
XM_054355104.1 → XP_054211079.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X7