Replication interactions
Interaction |
Pubs |
Knockdown of cytochrome b-245, beta polypeptide (CYBB) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
Knockdown of NOX2 and NOX4 by siRNA abrogates HIV-1 gp120-induced reactive oxygen species (ROS), suggesting that NOX2 and NOX4 are involved in ROS production through CYP2E1 in astrocytes |
PubMed
|
|
env
|
Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 |
PubMed
|
Nef
|
nef
|
NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells |
PubMed
|
Tat
|
tat
|
HIV-1 Tat C downregulates the expression of miR-17 to increase the expression of NOX2 and NOX4; overexpression of miR-17 inhibits NOX2 and NOX4 expression in human microglial cells |
PubMed
|
|
tat
|
HIV-1 Tat C upregulates NOX2 and NOX4 expression and increases ROS production in human brain cells |
PubMed
|
|
tat
|
Knocking down Nox2 by siRNA blocks HIV-1 Tat-induced reactive oxygen species (ROS) production, increase of NADPH oxidase activity, and Rac1 activation |
PubMed
|
|
tat
|
HIV-1 Tat downregulates the expression of cytochrome b-245, beta polypeptide (CYBB; NOX2) in human primary T cells |
PubMed
|
|
tat
|
Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 |
PubMed
|
|
tat
|
Knocking down oxidase Nox2 blocks Tat-induced cytoskeletal rearrangement |
PubMed
|
|
tat
|
HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 is blocked by NADPH oxidase (NOX2) inhibitor |
PubMed
|
|
tat
|
HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) |
PubMed
|
|
tat
|
Nox2 is involved in HIV-1 Tat-induced NADPH oxidase p65 and IKK phosphorylation |
PubMed
|
capsid
|
gag
|
HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 |
PubMed
|
Go to the HIV-1, Human Interaction Database