U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    OGT O-linked N-acetylglucosamine (GlcNAc) transferase [ Homo sapiens (human) ]

    Gene ID: 8473, updated on 27-Dec-2024

    Summary

    Official Symbol
    OGTprovided by HGNC
    Official Full Name
    O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by HGNC
    Primary source
    HGNC:HGNC:8127
    See related
    Ensembl:ENSG00000147162 MIM:300255; AllianceGenome:HGNC:8127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC
    Summary
    This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OGT in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71533104..71575892)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (69966355..70009143)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70752954..70795742)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20898 Neighboring gene inhibitor of growth family, X-linked (pseudogene) Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:70752005-70753204 Neighboring gene SOCS6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70798494-70799135 Neighboring gene germ cell nuclear acidic peptidase Neighboring gene Sharpr-MPRA regulatory region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29746 Neighboring gene C-X-C motif chemokine receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ23071, MGC22921

    Gene Ontology Provided by GOA

    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in apoptotic process PubMed 
    involved_in cellular response to glucose stimulus PubMed 
    involved_in chromatin organization  
    involved_in circadian regulation of gene expression  
    involved_in hemopoiesis PubMed 
    involved_in mitophagy PubMed 
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of non-canonical inflammasome complex assembly PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in negative regulation of protein ubiquitination PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of stem cell population maintenance PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of TORC1 signaling PubMed 
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of proteolysis PubMed 
    involved_in positive regulation of stem cell population maintenance PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose  
    involved_in positive regulation of translation PubMed 
    involved_in protein O-linked glycosylation  
    involved_in protein O-linked glycosylation PubMed 
    involved_in protein O-linked glycosylation PubMed 
    involved_in protein processing PubMed 
    involved_in regulation of Rac protein signal transduction PubMed 
    involved_in regulation of gluconeogenesis  
    involved_in regulation of glycolytic process PubMed 
    involved_in regulation of insulin receptor signaling pathway PubMed 
    involved_in regulation of necroptotic process  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  
    involved_in regulation of synapse assembly  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to insulin PubMed 
    involved_in response to nutrient PubMed 
    involved_in signal transduction PubMed 
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    part_of NSL complex PubMed 
    part_of Sin3-type complex PubMed 
    located_in cell projection  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in glutamatergic synapse  
    part_of histone acetyltransferase complex PubMed 
    located_in mitochondrial membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in plasma membrane PubMed 
    part_of protein N-acetylglucosaminyltransferase complex PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Names
    O-GlcNAc transferase p110 subunit
    O-GlcNAc transferase subunit p110
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
    O-linked N-acetylglucosamine transferase 110 kDa subunit
    UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
    uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
    NP_858058.1
    NP_858059.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015875.1 RefSeqGene

      Range
      5043..47831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181672.3 → NP_858058.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

      See identical proteins and their annotated locations for NP_858058.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF070560, BC038180, BX537844, DA460761
      Consensus CDS
      CCDS14414.1
      UniProtKB/Swiss-Prot
      O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57
      UniProtKB/TrEMBL
      A0A8V8TPA3
      Related
      ENSP00000362824.3, ENST00000373719.8
      Conserved Domains (3) summary
      TIGR02917
      Location:22 → 465
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:327 → 355
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:556 → 1024
      Glyco_transf_41; Glycosyl transferase family 41
    2. NM_181673.3 → NP_858059.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

      See identical proteins and their annotated locations for NP_858059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      BC014434, BX537844, DA460761
      Consensus CDS
      CCDS35502.1
      UniProtKB/TrEMBL
      A0A8V8TPA3
      Related
      ENSP00000362805.3, ENST00000373701.7
      Conserved Domains (3) summary
      TIGR02917
      Location:23 → 455
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:317 → 345
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:546 → 1014
      Glyco_transf_41; Glycosyl transferase family 41

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      71533104..71575892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      69966355..70009143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    External link. Please review our privacy policy.