U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CCL19 C-C motif chemokine ligand 19 [ Homo sapiens (human) ]

    Gene ID: 6363, updated on 10-Dec-2024

    Summary

    Official Symbol
    CCL19provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 19provided by HGNC
    Primary source
    HGNC:HGNC:10617
    See related
    Ensembl:ENSG00000172724 MIM:602227; AllianceGenome:HGNC:10617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELC; CKb11; MIP3B; MIP-3b; SCYA19
    Summary
    This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in appendix (RPKM 274.6), lymph node (RPKM 208.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCL19 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34689570..34691276, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34708593..34710301, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34689567..34691273, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19855 Neighboring gene uncharacterized LOC124902146 Neighboring gene uncharacterized LOC730098 Neighboring gene PHD finger protein 24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19856 Neighboring gene SPATA31 subfamily F member 1 Neighboring gene C-C motif chemokine ligand 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (9 hits/1251 screens)

    EBI GWAS Catalog

    Description
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef impairs the mobility of primary CD4+ lymphocytes and inhibits chemotaxis of primary T cells to CCL19 PubMed
    Pr55(Gag) gag The migration capacity of MVA-gag-infected human monocyte-derived dendritic cells is significantly higher in the presence of CCL19 than in the absence of this chemokine PubMed
    Tat tat HIV-1 Tat upregulates the expression of chemokine (C-C motif) ligand 19 (CCL19) in human primary T cells PubMed
    Vpu vpu HIV-1 Vpu inhibits the chemotactic potential of primary CD4+ T cells to migrate specifically toward CCL19 PubMed
    vpu Vpu-mediated downregulation of CCR7 upon viral infection results in an impaired ability of infected primary CD4+ T cells to respond to CCL19 PubMed
    capsid gag The migration capacity of PLA-p24-loaded human monocyte-derived dendritic cells is significantly higher in the presence of CCL19 than in the absence of this chemokine PubMed
    matrix gag Treatment of plasmacytoid dendritic cells (pDCs) with HIV-1 MA upregulates the expression of CCR7. Coculture with MA and CCL19 induces a dose-dependent migration of pDCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC34433

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding  
    enables CCR chemokine receptor binding PubMed 
    enables CCR10 chemokine receptor binding PubMed 
    enables CCR7 chemokine receptor binding  
    enables chemokine activity  
    enables chemokine activity PubMed 
    enables chemokine receptor binding PubMed 
    enables protein binding PubMed 
    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in T cell costimulation  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
    involved_in cell communication PubMed 
    involved_in cell maturation  
    involved_in cellular response to virus PubMed 
    involved_in chemokine-mediated signaling pathway  
    involved_in dendritic cell chemotaxis PubMed 
    involved_in eosinophil chemotaxis  
    involved_in establishment of T cell polarity PubMed 
    involved_in immune response PubMed 
    involved_in immunological synapse formation  
    involved_in inflammatory response  
    involved_in inflammatory response PubMed 
    involved_in intracellular calcium ion homeostasis PubMed 
    involved_in killing of cells of another organism PubMed 
    involved_in mature conventional dendritic cell differentiation  
    involved_in myeloid dendritic cell chemotaxis PubMed 
    involved_in negative regulation of dendritic cell apoptotic process PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of JNK cascade PubMed 
    acts_upstream_of positive regulation of JUN kinase activity  
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of T-helper 1 cell differentiation  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell motility PubMed 
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of dendritic cell antigen processing and presentation  
    involved_in positive regulation of dendritic cell dendrite assembly  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of glycoprotein biosynthetic process  
    involved_in positive regulation of interleukin-1 beta production  
    acts_upstream_of positive regulation of interleukin-12 production  
    involved_in positive regulation of neutrophil chemotaxis PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of receptor-mediated endocytosis  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in regulation of cell projection assembly  
    involved_in release of sequestered calcium ion into cytosol PubMed 
    involved_in response to nitric oxide PubMed 
    involved_in response to prostaglandin E PubMed 
    involved_in response to virus PubMed 
    Items 1 - 25 of 47
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  

    General protein information

    Preferred Names
    C-C motif chemokine 19
    Names
    CC chemokine ligand 19
    CK beta-11
    EBI1-ligand chemokine
    MIP-3-beta
    beta chemokine exodus-3
    chemokine (C-C motif) ligand 19
    epstein-Barr virus-induced molecule 1 ligand chemokine
    exodus-3
    macrophage inflammatory protein 3-beta
    small inducible cytokine subfamily A (Cys-Cys), member 19
    small-inducible cytokine A19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006274.3 → NP_006265.1  C-C motif chemokine 19 precursor

      See identical proteins and their annotated locations for NP_006265.1

      Status: REVIEWED

      Source sequence(s)
      AL162231
      Consensus CDS
      CCDS6570.1
      UniProtKB/Swiss-Prot
      O00697, O00736, Q99731
      UniProtKB/TrEMBL
      Q5VZ75, Q6IBD6
      Related
      ENSP00000308815.2, ENST00000311925.7
      Conserved Domains (1) summary
      cd01119
      Location:27 → 87
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      34689570..34691276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      34708593..34710301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.