YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: YWHABprovided by HGNC
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaprovided by HGNC
Primary source: HGNC:HGNC:12849
See related: Ensembl:ENSG00000166913 MIM:601289; AllianceGenome:HGNC:12849
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HS1; GW128; YWHAA; KCIP-1; HEL-S-1
Summary: This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (44885705..44908532)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (46621568..46644395)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (43514346..43537173)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
Title: miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
14-3-3beta isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
Title: 14-3-3β isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
Title: Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
Title: Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
The regulatory protein 14-3-3beta binds to the IQ motifs of myosin-IC independent of phosphorylation.
Title: The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.
YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization and its activity.
Title: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
YWHAB was identified and validated in association with pulmonary arterial hypertension progression, which might serve as a biomarker and/or therapeutic target for pulmonary arterial hypertension.
Title: Integrated bioinformatic analysis reveals YWHAB as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension.
the interaction of lncRNA RP11-732M18.3 with 14-3-3beta/alpha increases the degradation of the p21 protein. lncRNA RP11-732M18.3 promoted the recruitment of ubiquitin-conjugating enzyme E2 E1 to 14-3-3beta/alpha and the binding of 14-3-3beta/alpha with ubiquitin-conjugating enzyme E2 E1 (UBE2E1) promoted the degradation of p21.
Title: The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth.
14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis.
Title: Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
findings advance our understanding of how phosphorylation of lipin 1beta phosphatidate phosphatase regulates its interaction with 14-3-3beta protein and intracellular localization and uncover a mechanism by which CKII regulates cellular physiology.
Title: Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of WASF2	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120	PubMed
Vpr	vpr	HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells	PubMed
	vpr	Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25	PubMed
integrase	gag-pol	HIV-1 IN is identified to have a physical interaction with 14-3-3 protein beta/alpha (YWHAB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL022350 (e-PCR)
- UniSTS:71947

D20S556E (e-PCR)
- UniSTS:88619

YWHAB__1218 (e-PCR)
- UniSTS:277869

YWHAB__v346 (e-PCR)
- UniSTS:277869

Z94504 (e-PCR)
- UniSTS:56942

RH66089 (e-PCR)
- UniSTS:89219

SHGC-37252 (e-PCR)
- UniSTS:16827

D20S528E (e-PCR)
- UniSTS:150763

STS-X57346 (e-PCR)
- UniSTS:46319

D20S586E (e-PCR)
- UniSTS:48879

STS-N23075 (e-PCR)
- UniSTS:6129

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoserine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic sequestering of protein	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 14-3-3 protein beta/alpha

Names: 14-3-3 alpha; epididymis secretory protein Li 1; protein 1054; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003404.5 → NP_003395.1 14-3-3 protein beta/alpha

See identical proteins and their annotated locations for NP_003395.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AA845374, AK292717, AL008725, DB443535

Consensus CDS

CCDS13339.1

UniProtKB/Swiss-Prot

A8K9K2, E1P616, P31946

UniProtKB/TrEMBL

B5BU24, V9HWD6

Related

ENSP00000361930.3, ENST00000372839.7

Conserved Domains (1) summary

cd10022
Location:4 → 232

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
NM_139323.4 → NP_647539.1 14-3-3 protein beta/alpha

See identical proteins and their annotated locations for NP_647539.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AA845374, AL008725, BC001359, DB443535

Consensus CDS

CCDS13339.1

UniProtKB/Swiss-Prot

A8K9K2, E1P616, P31946

UniProtKB/TrEMBL

B5BU24, V9HWD6

Related

ENSP00000300161.4, ENST00000353703.9

Conserved Domains (1) summary

cd10022
Location:4 → 232

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

44885705..44908532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017028040.2 → XP_016883529.1 14-3-3 protein beta/alpha isoform X1

UniProtKB/TrEMBL

Q4VY19

Related

ENSP00000394729.1, ENST00000428262.1

Conserved Domains (1) summary

cl02098
Location:4 → 100

14-3-3; 14-3-3 domain