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    P2RY6 pyrimidinergic receptor P2Y6 [ Homo sapiens (human) ]

    Gene ID: 5031, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2RY6provided by HGNC
    Official Full Name
    pyrimidinergic receptor P2Y6provided by HGNC
    Primary source
    HGNC:HGNC:8543
    See related
    Ensembl:ENSG00000171631 MIM:602451; AllianceGenome:HGNC:8543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2Y6
    Summary
    The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2RY6 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73264506..73298625)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73193675..73227786)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72975551..73009670)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:72959838-72961037 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72975095-72975632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72981035-72981828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72981829-72982621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73000363-73000929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3737 Neighboring gene ARHGEF17 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73019433-73020310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73020316-73021136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5234 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73031799-73032452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73032453-73033105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73033106-73033758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73036372-73037023 Neighboring gene Sharpr-MPRA regulatory region 2623 Neighboring gene uncharacterized LOC124902710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73044313-73045026

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC15335

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled ADP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled ADP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled UDP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled UDP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled UTP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to purine-containing compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to pyrimidine ribonucleotide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to pyrimidine ribonucleotide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to pyrimidine ribonucleotide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inositol trisphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inositol trisphosphate biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transepithelial chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    P2Y purinoceptor 6
    Names
    G-coupled nucleotide receptor
    P2 purinoceptor
    P2Y6 receptor
    pyrimidinergic receptor P2Y, G-protein coupled, 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277204.2NP_001264133.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_001264133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF218005, BC009391, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000442551.1, ENST00000540124.6
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001277205.2NP_001264134.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_001264134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      AL525099, BC009391, BX397649, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000445652.1, ENST00000542092.5
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001277206.2NP_001264135.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_001264135.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      AP002761, BC009391, BQ718871, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000480966.1, ENST00000618468.5
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001277207.2NP_001264136.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_001264136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      AP002761, BC009391, BX337204, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000504879.1, ENST00000679753.1
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001277208.1NP_001264137.1  P2Y purinoceptor 6 isoform 2

      See identical proteins and their annotated locations for NP_001264137.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an alternate 5'-most exon and initiates translation at an alternate start codon so that the 5' UTR and 5' coding region differ compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
      Source sequence(s)
      BC009391, DR004482, HY271000
      UniProtKB/Swiss-Prot
      Q15077
      Conserved Domains (1) summary
      pfam00001
      Location:145401
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    6. NM_176796.3NP_789766.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_789766.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      BC009391, BX381745, BX397649, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000309771.2, ENST00000349767.6
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. NM_176797.3NP_789767.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_789767.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF007891, BC009391, BX397649, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000377217.2, ENST00000393592.7
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_176798.2NP_789768.1  P2Y purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_789768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF007892, BC009391, DR006998, HY271000
      Consensus CDS
      CCDS8220.1
      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000377216.1, ENST00000393591.5
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      73264506..73298625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545079.3XP_011543381.1  P2Y purinoceptor 6 isoform X3

      See identical proteins and their annotated locations for XP_011543381.1

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000443427.1, ENST00000540342.6
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_047427038.1XP_047282994.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    3. XM_011545076.3XP_011543378.1  P2Y purinoceptor 6 isoform X1

      UniProtKB/TrEMBL
      A0A7P0TA46
      Conserved Domains (1) summary
      pfam00001
      Location:114370
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_047427036.1XP_047282992.1  P2Y purinoceptor 6 isoform X2

      UniProtKB/TrEMBL
      A0A7P0TA46
    5. XM_047427037.1XP_047282993.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    6. XM_047427039.1XP_047282995.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    7. XM_006718571.4XP_006718634.1  P2Y purinoceptor 6 isoform X3

      See identical proteins and their annotated locations for XP_006718634.1

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000442990.1, ENST00000538328.2
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. XM_005274022.4XP_005274079.1  P2Y purinoceptor 6 isoform X3

      See identical proteins and their annotated locations for XP_005274079.1

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
      Related
      ENSP00000505646.1, ENST00000680955.1
      Conserved Domains (1) summary
      cd15379
      Location:27312
      7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      73193675..73227786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369000.1XP_054224975.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    2. XM_054368998.1XP_054224973.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    3. XM_054368994.1XP_054224969.1  P2Y purinoceptor 6 isoform X1

      UniProtKB/TrEMBL
      A0A7P0TA46
    4. XM_054368995.1XP_054224970.1  P2Y purinoceptor 6 isoform X2

      UniProtKB/TrEMBL
      A0A7P0TA46
    5. XM_054368997.1XP_054224972.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    6. XM_054369001.1XP_054224976.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    7. XM_054368996.1XP_054224971.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46
    8. XM_054368999.1XP_054224974.1  P2Y purinoceptor 6 isoform X3

      UniProtKB/Swiss-Prot
      Q15077, Q15754
      UniProtKB/TrEMBL
      A0A7P0TA46

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004154.3: Suppressed sequence

      Description
      NM_004154.3: This RefSeq was permanently suppressed because it contains the wrong CDS (incomplete at the 5' end).