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    ADGRL1 adhesion G protein-coupled receptor L1 [ Homo sapiens (human) ]

    Gene ID: 22859, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ADGRL1provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor L1provided by HGNC
    Primary source
    HGNC:HGNC:20973
    See related
    Ensembl:ENSG00000072071 MIM:616416; AllianceGenome:HGNC:20973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CL1; LEC2; CIRL1; LPHN1; DEDBANP
    Summary
    This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
    Expression
    Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRL1 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14147743..14206169, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14274383..14332836, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14258555..14316981, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14223743-14224430 Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10234 Neighboring gene uncharacterized LOC124904642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14155 Neighboring gene small integral membrane protein 46 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14156 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14247764-14248390 Neighboring gene Sharpr-MPRA regulatory region 12148 Neighboring gene ADGRL1 antisense RNA 1 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14258690-14259433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14278263-14278762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14320437-14320936 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:14328052-14328362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14332061-14332584 Neighboring gene RNA, 7SL, cytoplasmic 231, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14360564-14361081 Neighboring gene MPRA-validated peak3380 silencer Neighboring gene MPRA-validated peak3381 silencer Neighboring gene Sharpr-MPRA regulatory region 1520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14408885-14409384 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:14421820-14422074 Neighboring gene long intergenic non-protein coding RNA 1841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14429209-14429710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14429711-14430210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14444577-14445252 Neighboring gene MPRA-validated peak3382 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14449292-14449792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14449793-14450293 Neighboring gene long intergenic non-protein coding RNA 1842

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells. Sumbayev VV, et al. Oncotarget, 2016 Jul 19. PMID 27322212, Free PMC Article
    2. Association of the subunits of the calcium-independent receptor of α-latrotoxin. Serova OV, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20971062
    3. Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression. Sakhnevych SS, et al. Cell Mol Immunol, 2018 Nov. PMID 29907881, Free PMC Article
    4. Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways. Ovando-Zambrano JC, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31339586
    5. Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity. Dietzsch AN, et al. Signal Transduct Target Ther, 2024 Apr 26. PMID 38664368, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
      Title: Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
    2. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
      Title: ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
    3. results suggest that SSB splicing selectively affects the duality of LPHN1 signaling toward opposing cAMP pathways
      Title: Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.
    4. Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
      Title: Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
    5. These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction.
      Title: Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
    6. alterations in latrophilin expression occur in AML cells expressing P-gp
      Title: Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.
    7. Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia
      Title: Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells.
    8. A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma.
      Title: Latrophilin receptors: novel bronchodilator targets in asthma.
    9. Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW]
      Title: Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.
    10. In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex.
      Title: Association of the subunits of the calcium-independent receptor of α-latrotoxin.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental delay, behavioral abnormalities, and neuropsychiatric disorders
    MedGen: C5774224 OMIM: 620065 GeneReviews: Not available
    		not available

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables latrotoxin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables latrotoxin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L1
    Names
    CIRL-1
    calcium-independent alpha-latrotoxin receptor 1
    latrophilin-1
    lectomedin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008701.3 → NP_001008701.1  adhesion G protein-coupled receptor L1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001008701.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB020628, AF307079, BC002974, BC072445
      Consensus CDS
      CCDS32928.1
      UniProtKB/Swiss-Prot
      O94910, Q96IE7, Q9BU07, Q9HAR3
      Related
      ENSP00000340688.5, ENST00000340736.10
      Conserved Domains (8) summary
      smart00303
      Location:798 → 850
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476 → 539
      HormR; Domain present in hormone receptors
      PHA03247
      Location:398 → 482
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:857 → 1114
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1474
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:549 → 774
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    2. NM_014921.5 → NP_055736.2  adhesion G protein-coupled receptor L1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_055736.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AB020628, AF307079, BC002974, BC072445
      Consensus CDS
      CCDS12307.1
      UniProtKB/Swiss-Prot
      O94910
      Related
      ENSP00000355328.2, ENST00000361434.8
      Conserved Domains (8) summary
      smart00303
      Location:793 → 845
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471 → 534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 465
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:852 → 1109
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1108 → 1469
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 769
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      14147743..14206169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438418.1 → XP_047294374.1  adhesion G protein-coupled receptor L1 isoform X9

    2. XM_005259818.4 → XP_005259875.1  adhesion G protein-coupled receptor L1 isoform X5

      See identical proteins and their annotated locations for XP_005259875.1

      Conserved Domains (8) summary
      smart00303
      Location:793 → 845
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471 → 534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 465
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:852 → 1109
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1108 → 1493
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 769
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    3. XM_011527798.3 → XP_011526100.1  adhesion G protein-coupled receptor L1 isoform X3

      See identical proteins and their annotated locations for XP_011526100.1

      Conserved Domains (8) summary
      smart00303
      Location:800 → 852
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:478 → 541
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 497
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:859 → 1116
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1115 → 1500
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:551 → 776
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    4. XM_011527796.3 → XP_011526098.1  adhesion G protein-coupled receptor L1 isoform X2

      See identical proteins and their annotated locations for XP_011526098.1

      Conserved Domains (8) summary
      smart00303
      Location:805 → 857
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:483 → 546
      HormR; Domain present in hormone receptors
      PHA03247
      Location:398 → 502
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:864 → 1121
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1120 → 1505
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:556 → 781
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    5. XM_047438417.1 → XP_047294373.1  adhesion G protein-coupled receptor L1 isoform X8

    6. XM_017026477.2 → XP_016881966.1  adhesion G protein-coupled receptor L1 isoform X4

      Conserved Domains (8) summary
      smart00303
      Location:799 → 851
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:477 → 540
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 471
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:858 → 1115
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1114 → 1499
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:550 → 775
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    7. XM_017026479.2 → XP_016881968.1  adhesion G protein-coupled receptor L1 isoform X7

    8. XM_017026478.2 → XP_016881967.1  adhesion G protein-coupled receptor L1 isoform X6

      Conserved Domains (8) summary
      smart00303
      Location:806 → 858
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:484 → 547
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 537
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:865 → 1122
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1121 → 1482
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:557 → 782
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    9. XM_017026475.2 → XP_016881964.1  adhesion G protein-coupled receptor L1 isoform X1

      Conserved Domains (8) summary
      smart00303
      Location:806 → 858
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:484 → 547
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 503
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:865 → 1122
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1121 → 1506
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:557 → 782
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    10. XM_047438415.1 → XP_047294371.1  adhesion G protein-coupled receptor L1 isoform X5

    11. XM_017026476.2 → XP_016881965.1  adhesion G protein-coupled receptor L1 isoform X1

      Conserved Domains (8) summary
      smart00303
      Location:806 → 858
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:484 → 547
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 503
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:865 → 1122
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1121 → 1506
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:557 → 782
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    12. XM_047438416.1 → XP_047294372.1  adhesion G protein-coupled receptor L1 isoform X5

    13. XM_047438413.1 → XP_047294369.1  adhesion G protein-coupled receptor L1 isoform X1

    14. XM_047438414.1 → XP_047294370.1  adhesion G protein-coupled receptor L1 isoform X3

    15. XM_024451420.2 → XP_024307188.1  adhesion G protein-coupled receptor L1 isoform X1

      Conserved Domains (8) summary
      smart00303
      Location:806 → 858
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:484 → 547
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 503
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:865 → 1122
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1121 → 1506
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:557 → 782
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    16. XM_047438419.1 → XP_047294375.1  adhesion G protein-coupled receptor L1 isoform X12

    17. XM_017026480.2 → XP_016881969.2  adhesion G protein-coupled receptor L1 isoform X11

    18. XM_011527801.3 → XP_011526103.2  adhesion G protein-coupled receptor L1 isoform X10

    19. XM_017026481.2 → XP_016881970.1  adhesion G protein-coupled receptor L1 isoform X13

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160022.1 Reference GRCh38.p14 PATCHES

      Range
      359902..418328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332684.1 → XP_054188659.1  adhesion G protein-coupled receptor L1 isoform X9

    2. XM_054332679.1 → XP_054188654.1  adhesion G protein-coupled receptor L1 isoform X5

    3. XM_054332675.1 → XP_054188650.1  adhesion G protein-coupled receptor L1 isoform X3

    4. XM_054332674.1 → XP_054188649.1  adhesion G protein-coupled receptor L1 isoform X2

    5. XM_054332683.1 → XP_054188658.1  adhesion G protein-coupled receptor L1 isoform X8

    6. XM_054332677.1 → XP_054188652.1  adhesion G protein-coupled receptor L1 isoform X4

    7. XM_054332682.1 → XP_054188657.1  adhesion G protein-coupled receptor L1 isoform X7

    8. XM_054332681.1 → XP_054188656.1  adhesion G protein-coupled receptor L1 isoform X6

    9. XM_054332670.1 → XP_054188645.1  adhesion G protein-coupled receptor L1 isoform X1

    10. XM_054332678.1 → XP_054188653.1  adhesion G protein-coupled receptor L1 isoform X5

    11. XM_054332672.1 → XP_054188647.1  adhesion G protein-coupled receptor L1 isoform X1

    12. XM_054332680.1 → XP_054188655.1  adhesion G protein-coupled receptor L1 isoform X5

    13. XM_054332673.1 → XP_054188648.1  adhesion G protein-coupled receptor L1 isoform X1

    14. XM_054332676.1 → XP_054188651.1  adhesion G protein-coupled receptor L1 isoform X3

    15. XM_054332671.1 → XP_054188646.1  adhesion G protein-coupled receptor L1 isoform X1

    16. XM_054332687.1 → XP_054188662.1  adhesion G protein-coupled receptor L1 isoform X12

    17. XM_054332686.1 → XP_054188661.1  adhesion G protein-coupled receptor L1 isoform X11

    18. XM_054332685.1 → XP_054188660.1  adhesion G protein-coupled receptor L1 isoform X10

    19. XM_054332688.1 → XP_054188663.1  adhesion G protein-coupled receptor L1 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      14274383..14332836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320219.1 → XP_054176194.1  adhesion G protein-coupled receptor L1 isoform X9

    2. XM_054320214.1 → XP_054176189.1  adhesion G protein-coupled receptor L1 isoform X5

    3. XM_054320210.1 → XP_054176185.1  adhesion G protein-coupled receptor L1 isoform X3

    4. XM_054320209.1 → XP_054176184.1  adhesion G protein-coupled receptor L1 isoform X2

    5. XM_054320218.1 → XP_054176193.1  adhesion G protein-coupled receptor L1 isoform X8

    6. XM_054320212.1 → XP_054176187.1  adhesion G protein-coupled receptor L1 isoform X4

    7. XM_054320217.1 → XP_054176192.1  adhesion G protein-coupled receptor L1 isoform X7

    8. XM_054320216.1 → XP_054176191.1  adhesion G protein-coupled receptor L1 isoform X6

    9. XM_054320205.1 → XP_054176180.1  adhesion G protein-coupled receptor L1 isoform X1

    10. XM_054320213.1 → XP_054176188.1  adhesion G protein-coupled receptor L1 isoform X5

    11. XM_054320207.1 → XP_054176182.1  adhesion G protein-coupled receptor L1 isoform X1

    12. XM_054320215.1 → XP_054176190.1  adhesion G protein-coupled receptor L1 isoform X5

    13. XM_054320208.1 → XP_054176183.1  adhesion G protein-coupled receptor L1 isoform X1

    14. XM_054320211.1 → XP_054176186.1  adhesion G protein-coupled receptor L1 isoform X3

    15. XM_054320206.1 → XP_054176181.1  adhesion G protein-coupled receptor L1 isoform X1

    16. XM_054320222.1 → XP_054176197.1  adhesion G protein-coupled receptor L1 isoform X12

    17. XM_054320221.1 → XP_054176196.1  adhesion G protein-coupled receptor L1 isoform X11

    18. XM_054320220.1 → XP_054176195.1  adhesion G protein-coupled receptor L1 isoform X10

    19. XM_054320223.1 → XP_054176198.1  adhesion G protein-coupled receptor L1 isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94910.1 GenPept UniProtKB/Swiss-Prot:O94910

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