Dus3l dihydrouridine synthase 3-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dus3lprovided by RGD
Official Full Name: dihydrouridine synthase 3-likeprovided by RGD
Primary source: RGD:1563228
See related: EnsemblRapid:ENSRNOG00000050381 AllianceGenome:RGD:1563228
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA dihydrouridine synthase activity and tRNA-dihydrouridine47 synthase activity. Predicted to be involved in regulation of translation and tRNA dihydrouridine synthesis. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 73.9), Kidney (RPKM 69.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1680619..1685784)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (1593491..1598663)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10289440..10294213, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables mRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables mRNA dihydrouridine synthase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-dihydrouridine47 synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-dihydrouridine47 synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA-dihydrouridine47 synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA dihydrouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA dihydrouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in tRNA dihydrouridine synthesis	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

Names: mRNA-dihydrouridine synthase DUS3L

NP_001030095.1

EC 1.3.1.89

XP_006244376.1

EC 1.3.1.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034923.1 → NP_001030095.1 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

See identical proteins and their annotated locations for NP_001030095.1

Status: PROVISIONAL

Source sequence(s)

BC105780

UniProtKB/Swiss-Prot

Q3KRC5

UniProtKB/TrEMBL

A6KQU6, M0RAY0

Related

ENSRNOP00000066698.2, ENSRNOT00000072703.3

Conserved Domains (2) summary

COG0042
Location:287 → 566

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd02801
Location:296 → 528

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

1680619..1685784

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244314.5 → XP_006244376.1 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

UniProtKB/TrEMBL

A0A8I6ALK0

Conserved Domains (2) summary

COG0042
Location:183 → 462

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd02801
Location:192 → 424

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...