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    Dner delta/notch-like EGF repeat containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnerprovided by RGD
    Official Full Name
    delta/notch-like EGF repeat containingprovided by RGD
    Primary source
    RGD:1359385
    See related
    EnsemblRapid:ENSRNOG00000016640 AllianceGenome:RGD:1359385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in central nervous system development. Predicted to act upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Predicted to be located in several cellular components, including dendrite; early endosome; and neuronal cell body. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 197.7), Adrenal (RPKM 32.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dner in Genome Data Viewer
    Location:
    9q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93035108..93350568, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (85586985..85902461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (91965866..92291172, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene phosphotyrosine interaction domain containing 1 Neighboring gene uncharacterized LOC134480402 Neighboring gene uncharacterized LOC120094725 Neighboring gene uncharacterized LOC134480598 Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene F-box protein 36 Neighboring gene uncharacterized LOC102550706 Neighboring gene solute carrier family 16, member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. Eiraku M, et al. J Biol Chem, 2002 Jul 12. PMID 11950833
    2. DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Eiraku M, et al. Nat Neurosci, 2005 Jul. PMID 15965470
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch receptor processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    delta and Notch-like epidermal growth factor-related receptor
    Names
    delta/notch-like EGF-related receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399331.1 → NP_001386260.1  delta and Notch-like epidermal growth factor-related receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A1W2Q656, A6JWC6
      Related
      ENSRNOP00000076139.1, ENSRNOT00000093357.3
      Conserved Domains (1) summary
      cd00054
      Location:590 → 626
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      93035108..93350568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084678.2 → XP_038940606.1  delta and Notch-like epidermal growth factor-related receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6A870, Q5U215
      Related
      ENSRNOP00000088607.1, ENSRNOT00000022564.8
      Conserved Domains (1) summary
      cd00054
      Location:215 → 251
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014103.1: Suppressed sequence

      Description
      NM_001014103.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DNER (GeneID:92737).
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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