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    Pus3 pseudouridine synthase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315554, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pus3provided by RGD
    Official Full Name
    pseudouridine synthase 3provided by RGD
    Primary source
    RGD:1310757
    See related
    EnsemblRapid:ENSRNOG00000012994 AllianceGenome:RGD:1310757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310757
    Summary
    Predicted to enable tRNA pseudouridine(38/39) synthase activity. Predicted to act upstream of or within tRNA pseudouridine synthesis. Orthologous to human PUS3 (pseudouridine synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 83.2), Spleen (RPKM 69.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pus3 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (42168194..42176527)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (33910461..33918716)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (36760874..36769167)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene enolase 1, pseudogene 15 Neighboring gene DEAD-box helicase 25 Neighboring gene HYLS1, centriolar and ciliogenesis associated Neighboring gene prostate and testis expressed 4B Neighboring gene prostate and testis expressed 2 Neighboring gene prostate and testis expressed 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition. Shaheen R, et al. Hum Genet, 2016 Jul. PMID 27055666, Free PMC Article
    2. Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA. Chen J, et al. Biochemistry, 2000 Oct 17. PMID 11027153
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA pseudouridine(38/39) synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA pseudouridine(38/39) synthase
    Names
    pseudouridylate synthase 3
    tRNA pseudouridine synthase 3
    NP_001101604.1
    XP_017451107.1
    XP_017451108.1
    XP_063121493.1
    XP_063121494.1
    XP_063121495.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108134.2 → NP_001101604.1  tRNA pseudouridine(38/39) synthase

      See identical proteins and their annotated locations for NP_001101604.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158693
      UniProtKB/TrEMBL
      A6JYL0, B0BN58, F6RES9
      Conserved Domains (1) summary
      cd02569
      Location:66 → 328
      PseudoU_synth_ScPus3; Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      42168194..42176527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595618.3 → XP_017451107.1  tRNA pseudouridine(38/39) synthase isoform X1

      UniProtKB/TrEMBL
      A6JYL0, B0BN58, F6RES9
      Related
      ENSRNOP00000017648.4, ENSRNOT00000017648.8
      Conserved Domains (1) summary
      cd02569
      Location:66 → 328
      PseudoU_synth_ScPus3; Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like

    2. XM_063265424.1 → XP_063121494.1  tRNA pseudouridine(38/39) synthase isoform X1

      UniProtKB/TrEMBL
      A6JYL0, B0BN58, F6RES9

    3. XM_017595619.3 → XP_017451108.1  tRNA pseudouridine(38/39) synthase isoform X1

      UniProtKB/TrEMBL
      A6JYL0, B0BN58, F6RES9
      Conserved Domains (1) summary
      cd02569
      Location:66 → 328
      PseudoU_synth_ScPus3; Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like

    4. XM_063265423.1 → XP_063121493.1  tRNA pseudouridine(38/39) synthase isoform X1

      UniProtKB/TrEMBL
      A6JYL0, B0BN58, F6RES9

    5. XM_063265425.1 → XP_063121495.1  tRNA pseudouridine(38/39) synthase isoform X1

      UniProtKB/TrEMBL
      A6JYL0, B0BN58, F6RES9
    Nucleotide Protein Strain
    Heading Accession and Version

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