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    Rps15a ribosomal protein S15a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps15aprovided by RGD
    Official Full Name
    ribosomal protein S15aprovided by RGD
    Primary source
    RGD:619939
    See related
    EnsemblRapid:ENSRNOG00000018320 AllianceGenome:RGD:619939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including positive regulation of cell population proliferation; response to virus; and ribosomal small subunit biogenesis. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 4437.8), Thymus (RPKM 3778.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps15a in Genome Data Viewer
    Location:
    1q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (181854396..181861330, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (172420151..172427021, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (187759865..187766734, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485168 Neighboring gene uncharacterized LOC134485169 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 109 Neighboring gene ARL6 interacting reticulophagy regulator 1 Neighboring gene SMG1, nonsense mediated mRNA decay associated PI3K related kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism. Chen R, et al. Ann Clin Lab Sci, 2023 Mar. PMID 37094854
    2. The primary structure of rat ribosomal protein S15a. Chan YL, et al. Biochem Biophys Res Commun, 1994 May 16. PMID 8185605
    3. Human S15a expression is upregulated by hepatitis B virus X protein. Lian Z, et al. Mol Carcinog, 2004 May. PMID 15108328
    4. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. Collatz E, et al. J Biol Chem, 1977 Dec 25. PMID 925037
    5. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, et al. J Cell Biol, 2010 Sep 6. PMID 20819938, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism.
      Title: RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS8
    Names
    40S ribosomal protein S15a
    NP_446434.1
    XP_006230159.1
    XP_006230160.1
    XP_038968660.1
    XP_038968702.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053982.1 → NP_446434.1  small ribosomal subunit protein uS8

      See identical proteins and their annotated locations for NP_446434.1

      Status: PROVISIONAL

      Source sequence(s)
      X77953
      UniProtKB/Swiss-Prot
      P62246
      UniProtKB/TrEMBL
      A0A0G2JYA6, A6I8G0
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      181854396..181861330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230097.3 → XP_006230159.1  small ribosomal subunit protein uS8 isoform X1

      See identical proteins and their annotated locations for XP_006230159.1

      UniProtKB/Swiss-Prot
      P62246
      UniProtKB/TrEMBL
      A0A0G2JYA6, A6I8G0
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional

    2. XM_006230098.4 → XP_006230160.1  small ribosomal subunit protein uS8 isoform X1

      See identical proteins and their annotated locations for XP_006230160.1

      UniProtKB/Swiss-Prot
      P62246
      UniProtKB/TrEMBL
      A0A0G2JYA6, A6I8G0
      Related
      ENSRNOP00000075747.3, ENSRNOT00000092513.3
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional

    3. XM_039112732.1 → XP_038968660.1  small ribosomal subunit protein uS8 isoform X1

      UniProtKB/Swiss-Prot
      P62246
      UniProtKB/TrEMBL
      A0A0G2JYA6, A6I8G0
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional

    4. XM_039112774.2 → XP_038968702.1  small ribosomal subunit protein uS8 isoform X1

      UniProtKB/Swiss-Prot
      P62246
      UniProtKB/TrEMBL
      A0A0G2JYA6, A6I8G0
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62246.2 GenPept UniProtKB/Swiss-Prot:P62246

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