Slc46a3 solute carrier family 46, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc46a3provided by RGD
Official Full Name: solute carrier family 46, member 3provided by RGD
Primary source: RGD:1307594
See related: EnsemblRapid:ENSRNOG00000000937 AllianceGenome:RGD:1307594
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307594
Summary: Predicted to enable copper ion transmembrane transporter activity. Predicted to be involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine and vacuolar transmembrane transport. Predicted to act upstream of or within copper ion transmembrane transport. Predicted to be active in lysosomal membrane. Orthologous to human SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 79.2), Heart (RPKM 53.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (12176776..12193256)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (7140610..7157093)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (8725479..8741944)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	ISO Inferred from Sequence Orthology more info
involved_in vacuolar transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024968.1 → NP_001020139.1 lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor

See identical proteins and their annotated locations for NP_001020139.1

Status: PROVISIONAL

Source sequence(s)

BC091179

UniProtKB/Swiss-Prot

Q5BK75

UniProtKB/TrEMBL

A6K192

Related

ENSRNOP00000001243.5, ENSRNOT00000001243.8

Conserved Domains (1) summary

cl28910
Location:3 → 437

MFS; Major Facilitator Superfamily