Atp6v0a1 ATPase H+ transporting V0 subunit a1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6v0a1provided by RGD
Official Full Name: ATPase H+ transporting V0 subunit a1provided by RGD
Primary source: RGD:68405
See related: EnsemblRapid:ENSRNOG00000036814 AllianceGenome:RGD:68405
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atp6n1; Atp6n1a
Summary: Predicted to enable ATPase binding activity. Predicted to be involved in regulation of macroautophagy; synaptic vesicle lumen acidification; and vacuolar acidification. Located in terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 104. Orthologous to human ATP6V0A1 (ATPase H+ transporting V0 subunit a1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 351.9), Heart (RPKM 154.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86436089..86490185)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85935802..85989901)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88914264..88967736)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NGF-Induced Upregulation of CGRP in Orofacial Pain Induced by Tooth Movement Is Dependent on Atp6v0a1 and Vesicle Release.
Title: NGF-Induced Upregulation of CGRP in Orofacial Pain Induced by Tooth Movement Is Dependent on Atp6v0a1 and Vesicle Release.
Mild hypothermia significantly increased V0a1 compared to NT-3 h; V0a1 expression was associated with a decrease in the cleaved caspase 3 expression. These findings suggested that mild hypothermia inhibits CA-induced apoptosis in the hippocampus, which may be associated with reduced V-ATPase impairment.
Title: Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest.
V-ATPase membrane domain would allow the exocytotic machinery to discriminate fully loaded and acidified vesicles from vesicles undergoing neurotransmitter reloading.
Title: The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery.
Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase.
Title: Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase.
Voa1 and Voa2 cooperatively regulate the acidification and transmitter uptake/storage of dense-core vesicles, whereas they might not be as critical for exocytosis as recently proposed.
Title: Vacuolar H(+)-ATPase subunits Voa1 and Voa2 cooperatively regulate secretory vesicle acidification, transmitter uptake, and storage.
alternative splicing of exon N controls differential sorting of a1 variants to nerve terminals or distal dendrites, whereas exon C regulates their neuronal expression
Title: Alternative splicing controls neuronal expression of v-ATPase subunit a1 and sorting to nerve terminals.
In nephrotic rats, the rate of uptake of albumin by the proximal tubule (PT) is decreased. This is consistent with reduced expression of clathrin, megalin, and vacuolar H(+)-ATPase A subunit, proteins that are critical components of PT endocytosis.
Title: The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.
Thus, our data demonstrate that the multiple fusion steps in GLUT4 trafficking have differential quantitative requirements for NSF activity.
Title: Demonstration of differential quantitative requirements for NSF among multiple vesicle fusion pathways of GLUT4 using a dominant-negative ATPase-deficient NSF.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF412836 (e-PCR)
- UniSTS:248324

RH125015 (e-PCR)
- UniSTS:161837

RH144379 (e-PCR)
- UniSTS:233624

RH132477 (e-PCR)
- UniSTS:215760

RH132239 (e-PCR)
- UniSTS:215522

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle lumen acidification	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	HDA more info	PubMed
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: V-type proton ATPase 116 kDa subunit a 1

Names: ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal V0 subunit A1; ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a; V-ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; v-H+ATPase subunit a1; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit a

NP_113792.2

EC 7.1.2.2

XP_006247357.1

EC 7.1.2.2

XP_006247358.1

EC 7.1.2.2

XP_006247359.1

EC 7.1.2.2

XP_017452683.1

EC 7.1.2.2

XP_017452684.1

EC 7.1.2.2

XP_017452685.1

EC 7.1.2.2

XP_017452686.1

EC 7.1.2.2

XP_017452688.1

EC 7.1.2.2

XP_017452689.1

EC 7.1.2.2

XP_038941727.1

EC 7.1.2.2

XP_038941729.1

EC 7.1.2.2

XP_063124915.1

EC 7.1.2.2

XP_063124916.1

EC 7.1.2.2

XP_063124917.1

EC 7.1.2.2

XP_063124918.1

EC 7.1.2.2

XP_063124919.1

EC 7.1.2.2

XP_063124920.1

EC 7.1.2.2

XP_063124921.1

EC 7.1.2.2

XP_063124923.1

EC 7.1.2.2

XP_063124924.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031604.2 → NP_113792.2 V-type proton ATPase 116 kDa subunit a 1

See identical proteins and their annotated locations for NP_113792.2

Status: VALIDATED

Source sequence(s)

CB586356, CB770675, CB787072, CO560122, M58758

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B5

Conserved Domains (1) summary

pfam01496
Location:27 → 828

V_ATPase_I; V-type ATPase 116kDa subunit family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86436089..86490185

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597194.2 → XP_017452683.1 V-type proton ATPase 116 kDa subunit a 1 isoform X1

UniProtKB/Swiss-Prot

P25286

Conserved Domains (1) summary

pfam01496
Location:27 → 860

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_017597196.2 → XP_017452685.1 V-type proton ATPase 116 kDa subunit a 1 isoform X2

UniProtKB/Swiss-Prot

P25286
XM_006247295.4 → XP_006247357.1 V-type proton ATPase 116 kDa subunit a 1 isoform X4

See identical proteins and their annotated locations for XP_006247357.1

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B4

Related

ENSRNOP00000071954.2, ENSRNOT00000087076.3

Conserved Domains (1) summary

pfam01496
Location:27 → 835

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_006247296.4 → XP_006247358.1 V-type proton ATPase 116 kDa subunit a 1 isoform X5

See identical proteins and their annotated locations for XP_006247358.1

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B3

Conserved Domains (1) summary

pfam01496
Location:27 → 829

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_017597200.2 → XP_017452689.1 V-type proton ATPase 116 kDa subunit a 1 isoform X8

UniProtKB/Swiss-Prot

P25286
XM_017597197.2 → XP_017452686.1 V-type proton ATPase 116 kDa subunit a 1 isoform X3

UniProtKB/Swiss-Prot

P25286

Related

ENSRNOP00000102690.1, ENSRNOT00000138459.1
XM_039085801.1 → XP_038941729.1 V-type proton ATPase 116 kDa subunit a 1 isoform X9

UniProtKB/Swiss-Prot

P25286

Related

ENSRNOP00000109984.1, ENSRNOT00000134551.1

Conserved Domains (1) summary

pfam01496
Location:27 → 786

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_063268854.1 → XP_063124924.1 V-type proton ATPase 116 kDa subunit a 1 isoform X10
XM_006247297.5 → XP_006247359.1 V-type proton ATPase 116 kDa subunit a 1 isoform X7

See identical proteins and their annotated locations for XP_006247359.1

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

D4ACY5, Q2I6B2

Conserved Domains (1) summary

pfam01496
Location:27 → 822

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_017597195.3 → XP_017452684.1 V-type proton ATPase 116 kDa subunit a 1 isoform X1

UniProtKB/Swiss-Prot

P25286

Conserved Domains (1) summary

pfam01496
Location:27 → 860

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_063268845.1 → XP_063124915.1 V-type proton ATPase 116 kDa subunit a 1 isoform X4

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B4
XM_063268847.1 → XP_063124917.1 V-type proton ATPase 116 kDa subunit a 1 isoform X5

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B3
XM_017597199.3 → XP_017452688.1 V-type proton ATPase 116 kDa subunit a 1 isoform X3

UniProtKB/Swiss-Prot

P25286
XM_063268848.1 → XP_063124918.1 V-type proton ATPase 116 kDa subunit a 1 isoform X6

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B5
XM_063268851.1 → XP_063124921.1 V-type proton ATPase 116 kDa subunit a 1 isoform X7

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

D4ACY5, Q2I6B2
XM_063268853.1 → XP_063124923.1 V-type proton ATPase 116 kDa subunit a 1 isoform X9

UniProtKB/Swiss-Prot

P25286
XM_063268849.1 → XP_063124919.1 V-type proton ATPase 116 kDa subunit a 1 isoform X6

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B5
XM_039085799.2 → XP_038941727.1 V-type proton ATPase 116 kDa subunit a 1 isoform X1

UniProtKB/Swiss-Prot

P25286

Conserved Domains (1) summary

pfam01496
Location:27 → 860

V_ATPase_I; V-type ATPase 116kDa subunit family
XM_063268846.1 → XP_063124916.1 V-type proton ATPase 116 kDa subunit a 1 isoform X4

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B4
XM_063268850.1 → XP_063124920.1 V-type proton ATPase 116 kDa subunit a 1 isoform X6

UniProtKB/Swiss-Prot

P25286

UniProtKB/TrEMBL

Q2I6B5