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    Tubgcp2 tubulin gamma complex component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tubgcp2provided by RGD
    Official Full Name
    tubulin gamma complex component 2provided by RGD
    Primary source
    RGD:1309597
    See related
    EnsemblRapid:ENSRNOG00000018137 AllianceGenome:RGD:1309597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and nervous system development. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of gamma-tubulin complex. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 155.0), Thymus (RPKM 111.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tubgcp2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204220725..204247460, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194791113..194817807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212333740..212359352, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sperm flagellar protein 1-like Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene uncharacterized LOC134485200 Neighboring gene 60S ribosomal protein L36-like Neighboring gene zinc finger protein 511 Neighboring gene 5'-nucleotidase, cytosolic IIIA, pseudogene 1 Neighboring gene msh homeobox 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, et al. Pflugers Arch, 2005 Oct. PMID 16025302
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 2
    Names
    a disintegrin and metalloprotease domain 8
    tubulin, gamma complex associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107560.2 → NP_001101030.1  gamma-tubulin complex component 2

      See identical proteins and their annotated locations for NP_001101030.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166857
      UniProtKB/TrEMBL
      A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
      Related
      ENSRNOP00000024573.3, ENSRNOT00000024573.6
      Conserved Domains (2) summary
      pfam04130
      Location:509 → 868
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:218 → 506
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      204220725..204247460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263839.1 → XP_063119909.1  gamma-tubulin complex component 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B530

    2. XM_006230457.4 → XP_006230519.1  gamma-tubulin complex component 2 isoform X1

      See identical proteins and their annotated locations for XP_006230519.1

      UniProtKB/TrEMBL
      A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
      Conserved Domains (2) summary
      pfam04130
      Location:509 → 868
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:218 → 506
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    3. XM_006230460.4 → XP_006230522.1  gamma-tubulin complex component 2 isoform X1

      See identical proteins and their annotated locations for XP_006230522.1

      UniProtKB/TrEMBL
      A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
      Conserved Domains (2) summary
      pfam04130
      Location:509 → 868
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:218 → 506
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    4. XM_006230458.3 → XP_006230520.1  gamma-tubulin complex component 2 isoform X1

      See identical proteins and their annotated locations for XP_006230520.1

      UniProtKB/TrEMBL
      A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
      Conserved Domains (2) summary
      pfam04130
      Location:509 → 868
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:218 → 506
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    5. XM_006230459.5 → XP_006230521.1  gamma-tubulin complex component 2 isoform X1

      See identical proteins and their annotated locations for XP_006230521.1

      UniProtKB/TrEMBL
      A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
      Conserved Domains (2) summary
      pfam04130
      Location:509 → 868
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:218 → 506
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    6. XM_039078900.2 → XP_038934828.1  gamma-tubulin complex component 2 isoform X4

      Conserved Domains (2) summary
      pfam04130
      Location:214 → 573
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 211
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    7. XM_063263843.1 → XP_063119913.1  gamma-tubulin complex component 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6B530
      Related
      ENSRNOP00000096948.1, ENSRNOT00000105932.2

    RNA

    1. XR_010053003.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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