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    KIF19 kinesin family member 19 [ Homo sapiens (human) ]

    Gene ID: 124602, updated on 27-Dec-2024

    Summary

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    Official Symbol
    KIF19provided by HGNC
    Official Full Name
    kinesin family member 19provided by HGNC
    Primary source
    HGNC:HGNC:26735
    See related
    Ensembl:ENSG00000196169 MIM:619610; AllianceGenome:HGNC:26735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIF19A
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in axonemal microtubule depolymerization; microtubule-based movement; and plus-end specific microtubule depolymerization. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen (RPKM 3.3), duodenum (RPKM 1.5) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF19 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74326226..74355820)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75216872..75246454)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72322365..72351959)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72220111-72220644 Neighboring gene tweety family member 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72241021-72241915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72280764-72281359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72285237-72285737 Neighboring gene dynein axonemal intermediate chain 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:72292700-72292934 Neighboring gene uncharacterized LOC105371891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8928 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:72324530-72325444 Neighboring gene Sharpr-MPRA regulatory region 11842 Neighboring gene uncharacterized LOC107985078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72348389-72348919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72353094-72353966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72364259-72365247 Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. All kinesin superfamily protein, KIF, genes in mouse and human. Miki H, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416179, Free PMC Article
    2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
    3. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Yang JS, et al. Nat Commun, 2018 Sep 14. PMID 30217970, Free PMC Article
    4. FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia. Zhu XN, et al. J Hematol Oncol, 2023 Feb 11. PMID 36774506, Free PMC Article
    5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37300

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plus-end specific microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153209.4 → NP_694941.2  kinesin-like protein KIF19

      See identical proteins and their annotated locations for NP_694941.2

      Status: VALIDATED

      Source sequence(s)
      AA527573, AC103809, AW014742, AW339468, BC110989, BE219924, DA955730
      Consensus CDS
      CCDS32718.2
      UniProtKB/Swiss-Prot
      A6NLG2, B7ZKR1, Q2TAC6, Q52M87, Q8N1X8, Q8TAB6
      Related
      ENSP00000374566.4, ENST00000389916.5
      Conserved Domains (2) summary
      smart00129
      Location:14 → 353
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:11 → 346
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74326226..74355820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024150.2 → XP_016879639.1  kinesin-like protein KIF19 isoform X1

    2. XM_017024151.2 → XP_016879640.1  kinesin-like protein KIF19 isoform X2

    3. XM_005257029.2 → XP_005257086.1  kinesin-like protein KIF19 isoform X3

      Conserved Domains (2) summary
      smart00129
      Location:14 → 353
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:11 → 346
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    4. XM_017024152.2 → XP_016879641.1  kinesin-like protein KIF19 isoform X4

    5. XM_017024153.2 → XP_016879642.1  kinesin-like protein KIF19 isoform X5

    6. XM_005257030.2 → XP_005257087.1  kinesin-like protein KIF19 isoform X6

      Conserved Domains (2) summary
      smart00129
      Location:14 → 311
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:11 → 304
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    7. XM_017024154.2 → XP_016879643.1  kinesin-like protein KIF19 isoform X7

    8. XM_047435317.1 → XP_047291273.1  kinesin-like protein KIF19 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75216872..75246454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314995.1 → XP_054170970.1  kinesin-like protein KIF19 isoform X1

    2. XM_054314996.1 → XP_054170971.1  kinesin-like protein KIF19 isoform X2

    3. XM_054314997.1 → XP_054170972.1  kinesin-like protein KIF19 isoform X3

    4. XM_054314998.1 → XP_054170973.1  kinesin-like protein KIF19 isoform X4

    5. XM_054314999.1 → XP_054170974.1  kinesin-like protein KIF19 isoform X5

    6. XM_054315000.1 → XP_054170975.1  kinesin-like protein KIF19 isoform X6

    7. XM_054315001.1 → XP_054170976.1  kinesin-like protein KIF19 isoform X7

    8. XM_054315002.1 → XP_054170977.1  kinesin-like protein KIF19 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TAC6.2 GenPept UniProtKB/Swiss-Prot:Q2TAC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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