ATAD2B ATPase family AAA domain containing 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATAD2Bprovided by HGNC
Official Full Name: ATPase family AAA domain containing 2Bprovided by HGNC
Primary source: HGNC:HGNC:29230
See related: Ensembl:ENSG00000119778 MIM:615347; AllianceGenome:HGNC:29230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in lymph node (RPKM 1.9), testis (RPKM 1.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p24.1-p23.3

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (23677969..23927123, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (23719586..23961815, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (23971534..24149993, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ATAD2B may play a role in neuronal differentiation and tumor progression.
Title: ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-142120 (e-PCR)
- UniSTS:171267

RH16288 (e-PCR)
- UniSTS:4125

WI-14281 (e-PCR)
- UniSTS:83547

RH126627 (e-PCR)
- UniSTS:208773

SHGC-34850 (e-PCR)
- UniSTS:80036

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATPase family AAA domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029017.3 RefSeqGene

Range

5000..183459

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001242338.3 → NP_001229267.2 ATPase family AAA domain-containing protein 2B isoform 2

Status: REVIEWED

Source sequence(s)

AB033066, AC066692, AK094821, BC171846, BM974506

UniProtKB/Swiss-Prot

Q9ULI0

Conserved Domains (4) summary

cd05528
Location:960 → 1066

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:433 → 574

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:852 → 1081

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:438 → 572

AAA; ATPase family associated with various cellular activities (AAA)
NM_001354107.2 → NP_001341036.1 ATPase family AAA domain-containing protein 2B isoform 3

Status: REVIEWED

Source sequence(s)

AC009242, AC066692, AC079924, BM974506, KF456640

Conserved Domains (2) summary

cd05528
Location:974 → 1080

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

cl27568
Location:411 → 683

TIP49; TIP49 C-terminus
NM_017552.4 → NP_060022.2 ATPase family AAA domain-containing protein 2B isoform 1

Status: REVIEWED

Source sequence(s)

AB033066, AC066692, AK094821, AK125718, BC171846, BM974506

Consensus CDS

CCDS46227.1

UniProtKB/Swiss-Prot

B9ZVQ5, Q6ZNA6, Q8N9E7, Q9ULI0

Related

ENSP00000238789.5, ENST00000238789.10

Conserved Domains (4) summary

cd05528
Location:960 → 1071

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:433 → 574

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:852 → 1086

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:438 → 572

AAA; ATPase family associated with various cellular activities (AAA)

RNA

NR_125717.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AB033066, AC066692, AK094821, BC171846, BM974506

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

23677969..23927123 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047444799.1 → XP_047300755.1 ATPase family AAA domain-containing protein 2B isoform X1
XM_006712030.5 → XP_006712093.1 ATPase family AAA domain-containing protein 2B isoform X6

Conserved Domains (4) summary

cd05528
Location:974 → 1085

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:866 → 1100

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532920.4 → XP_011531222.1 ATPase family AAA domain-containing protein 2B isoform X4

Conserved Domains (4) summary

cd05528
Location:960 → 1071

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:433 → 574

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:852 → 1086

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:438 → 572

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532919.4 → XP_011531221.1 ATPase family AAA domain-containing protein 2B isoform X3

Conserved Domains (4) summary

cd05528
Location:974 → 1080

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:866 → 1095

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532918.4 → XP_011531220.1 ATPase family AAA domain-containing protein 2B isoform X2

Conserved Domains (4) summary

cd05528
Location:974 → 1085

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:866 → 1100

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_005264372.5 → XP_005264429.2 ATPase family AAA domain-containing protein 2B isoform X5

Conserved Domains (4) summary

cd05528
Location:974 → 1085

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:866 → 1100

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532924.4 → XP_011531226.1 ATPase family AAA domain-containing protein 2B isoform X7

Conserved Domains (3) summary

cd05528
Location:974 → 1059

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532925.4 → XP_011531227.1 ATPase family AAA domain-containing protein 2B isoform X8

Conserved Domains (3) summary

cd05528
Location:974 → 1059

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_047444801.1 → XP_047300757.1 ATPase family AAA domain-containing protein 2B isoform X11
XM_047444800.1 → XP_047300756.1 ATPase family AAA domain-containing protein 2B isoform X10
XM_006712031.5 → XP_006712094.1 ATPase family AAA domain-containing protein 2B isoform X9

Conserved Domains (3) summary

cd05528
Location:974 → 1058

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_047444803.1 → XP_047300759.1 ATPase family AAA domain-containing protein 2B isoform X13
XM_047444802.1 → XP_047300758.1 ATPase family AAA domain-containing protein 2B isoform X12
XM_011532928.3 → XP_011531230.1 ATPase family AAA domain-containing protein 2B isoform X14

See identical proteins and their annotated locations for XP_011531230.1

Conserved Domains (2) summary

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532929.4 → XP_011531231.1 ATPase family AAA domain-containing protein 2B isoform X15

Conserved Domains (2) summary

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_011532931.4 → XP_011531233.1 ATPase family AAA domain-containing protein 2B isoform X17

Conserved Domains (2) summary

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_047444804.1 → XP_047300760.1 ATPase family AAA domain-containing protein 2B isoform X14
XM_047444805.1 → XP_047300761.1 ATPase family AAA domain-containing protein 2B isoform X18
XM_011532930.4 → XP_011531232.1 ATPase family AAA domain-containing protein 2B isoform X16

Conserved Domains (2) summary

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_047444806.1 → XP_047300762.1 ATPase family AAA domain-containing protein 2B isoform X20
XM_011532932.3 → XP_011531234.1 ATPase family AAA domain-containing protein 2B isoform X19

See identical proteins and their annotated locations for XP_011531234.1

Conserved Domains (2) summary

smart00382
Location:447 → 588

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:452 → 586

AAA; ATPase family associated with various cellular activities (AAA)
XM_047444808.1 → XP_047300764.1 ATPase family AAA domain-containing protein 2B isoform X22
XM_047444807.1 → XP_047300763.1 ATPase family AAA domain-containing protein 2B isoform X21

RNA

XR_001738780.3 RNA Sequence
XR_001738782.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

23719586..23961815 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054342610.1 → XP_054198585.1 ATPase family AAA domain-containing protein 2B isoform X1
XM_054342616.1 → XP_054198591.1 ATPase family AAA domain-containing protein 2B isoform X23
XM_054342611.1 → XP_054198586.1 ATPase family AAA domain-containing protein 2B isoform X1
XM_054342614.1 → XP_054198589.1 ATPase family AAA domain-containing protein 2B isoform X4
XM_054342613.1 → XP_054198588.1 ATPase family AAA domain-containing protein 2B isoform X3
XM_054342612.1 → XP_054198587.1 ATPase family AAA domain-containing protein 2B isoform X2
XM_054342615.1 → XP_054198590.1 ATPase family AAA domain-containing protein 2B isoform X5
XM_054342617.1 → XP_054198592.1 ATPase family AAA domain-containing protein 2B isoform X7
XM_054342618.1 → XP_054198593.1 ATPase family AAA domain-containing protein 2B isoform X8
XM_054342621.1 → XP_054198596.1 ATPase family AAA domain-containing protein 2B isoform X11
XM_054342620.1 → XP_054198595.1 ATPase family AAA domain-containing protein 2B isoform X10
XM_054342619.1 → XP_054198594.1 ATPase family AAA domain-containing protein 2B isoform X9
XM_054342623.1 → XP_054198598.1 ATPase family AAA domain-containing protein 2B isoform X13
XM_054342622.1 → XP_054198597.1 ATPase family AAA domain-containing protein 2B isoform X12
XM_054342624.1 → XP_054198599.1 ATPase family AAA domain-containing protein 2B isoform X14
XM_054342626.1 → XP_054198601.1 ATPase family AAA domain-containing protein 2B isoform X15
XM_054342628.1 → XP_054198603.1 ATPase family AAA domain-containing protein 2B isoform X17
XM_054342625.1 → XP_054198600.1 ATPase family AAA domain-containing protein 2B isoform X14
XM_054342627.1 → XP_054198602.1 ATPase family AAA domain-containing protein 2B isoform X16
XM_054342629.1 → XP_054198604.1 ATPase family AAA domain-containing protein 2B isoform X18
XM_054342631.1 → XP_054198606.1 ATPase family AAA domain-containing protein 2B isoform X20
XM_054342630.1 → XP_054198605.1 ATPase family AAA domain-containing protein 2B isoform X19
XM_054342633.1 → XP_054198608.1 ATPase family AAA domain-containing protein 2B isoform X22
XM_054342632.1 → XP_054198607.1 ATPase family AAA domain-containing protein 2B isoform X21