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    TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 23118, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAB2provided by HGNC
    Official Full Name
    TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17075
    See related
    Ensembl:ENSG00000055208 MIM:605101; AllianceGenome:HGNC:17075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHTD2; TAB-2; MAP3K7IP2
    Summary
    The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAB2 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149217926..149411607)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150417736..150611453)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149539062..149732743)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25246 Neighboring gene Sharpr-MPRA regulatory region 12512 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17656 Neighboring gene uncharacterized LOC124901426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25250 Neighboring gene MPRA-validated peak6208 silencer Neighboring gene MPRA-validated peak6209 silencer Neighboring gene TAB2 antisense RNA 1 Neighboring gene MPRA-validated peak6210 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17657 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25252 Neighboring gene MPRA-validated peak6211 silencer Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25254 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:149699707-149700906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149746425-149746924 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149753111-149753397 Neighboring gene small ubiquitin like modifier 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149761776-149762690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149772303-149772854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149772855-149773406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25256 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149794343-149794528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149802875-149803730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149805477-149806341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25260 Neighboring gene coiled-coil domain containing 59 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population. Shen C, et al. Biomark Med, 2020 Apr. PMID 32270697
    2. A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. Owerbach D, et al. Diabetes, 2004 Jul. PMID 15220215
    3. There is more to it than just congenital heart defects - The phenotypic spectrum of TAB2-related syndrome. Westphal DS, et al. Gene, 2022 Mar 10. PMID 34995729
    4. Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement. Micale L, et al. Genet Med, 2022 Feb. PMID 34906501
    5. TAB2 variants cause cardiovascular heart disease, connective tissue disorder, and developmental delay. Hanson J, et al. Clin Genet, 2022 Feb. PMID 34741306, Free PMC Article

    See all (244) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3-generation family.
      Title: Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3-generation family.
    2. Expanding the phenotype of TAB2 variants and literature review.
      Title: Expanding the phenotype of TAB2 variants and literature review.
    3. TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
      Title: TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
    4. [Association Between TAB2 Gene Polymorphisms and Susceptibility to Cryptorchidism in Han Chinese Population in Southwest China].
      Title: [Association Between TAB2 Gene Polymorphisms and Susceptibility to Cryptorchidism in Han Chinese Population in Southwest China].
    5. TAB2 variants cause cardiovascular heart disease, connective tissue disorder, and developmental delay.
      Title: TAB2 variants cause cardiovascular heart disease, connective tissue disorder, and developmental delay.
    6. TAB2 deletions and variants cause a highly recognisable syndrome with mitral valve disease, cardiomyopathy, short stature and hypermobility.
      Title: TAB2 deletions and variants cause a highly recognisable syndrome with mitral valve disease, cardiomyopathy, short stature and hypermobility.
    7. Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement.
      Title: Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement.
    8. Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.
      Title: Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.
    9. There is more to it than just congenital heart defects - The phenotypic spectrum of TAB2-related syndrome.
      Title: There is more to it than just congenital heart defects - The phenotypic spectrum of TAB2-related syndrome.
    10. Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
      Title: Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Congenital heart defects, multiple types, 2
    MedGen: C3554279 OMIM: 614980 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-05-27)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2020-05-27)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Wnt signaling and Dupuytren's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2; MAP3K7IP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of TAB-2 PubMed
    capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21885, KIAA0733, DKFZp781G0741

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of autophagy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Names
    TAK1-binding protein 2
    mitogen-activated protein kinase kinase kinase 7-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021386.2 RefSeqGene

      Range
      104789..198684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001292034.3 → NP_001278963.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_001278963.1

      Status: REVIEWED

      Source sequence(s)
      AB018276, AL138727, BC035910
      Consensus CDS
      CCDS5214.1
      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
      Related
      ENSP00000490618.1, ENST00000637181.2
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. NM_001292035.3 → NP_001278964.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001278964.1

      Status: REVIEWED

      Source sequence(s)
      AK295750, BC035910, BX645362
      UniProtKB/TrEMBL
      B4DIR9
      Conserved Domains (3) summary
      smart00547
      Location:635 → 658
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:636 → 655
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl00087
      Location:502 → 570
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. NM_001369506.1 → NP_001356435.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL031133, AL138727, AL139103
      Consensus CDS
      CCDS5214.1
      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    4. NM_015093.6 → NP_055908.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_055908.1

      Status: REVIEWED

      Source sequence(s)
      AK307650, AK315038, BC035910
      Consensus CDS
      CCDS5214.1
      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RNA

    1. NR_125861.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI159838, BX645362, DB467477

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149217926..149411607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535633.3 → XP_011533935.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011533935.1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
      Related
      ENSP00000356426.1, ENST00000367456.5
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. XM_047418487.1 → XP_047274443.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    3. XM_047418489.1 → XP_047274445.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    4. XM_047418486.1 → XP_047274442.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    5. XM_047418488.1 → XP_047274444.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    6. XM_017010592.3 → XP_016866081.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    7. XM_047418485.1 → XP_047274441.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    8. XM_047418490.1 → XP_047274446.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      150417736..150611453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354841.1 → XP_054210816.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    2. XM_054354843.1 → XP_054210818.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    3. XM_054354840.1 → XP_054210815.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    4. XM_054354842.1 → XP_054210817.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    5. XM_054354845.1 → XP_054210820.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    6. XM_054354844.1 → XP_054210819.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    7. XM_054354839.1 → XP_054210814.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145342.1: Suppressed sequence

      Description
      NM_145342.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYJ8.1 GenPept UniProtKB/Swiss-Prot:Q9NYJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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