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    MARF1 meiosis regulator and mRNA stability factor 1 [ Homo sapiens (human) ]

    Gene ID: 9665, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MARF1provided by HGNC
    Official Full Name
    meiosis regulator and mRNA stability factor 1provided by HGNC
    Primary source
    HGNC:HGNC:29562
    See related
    Ensembl:ENSG00000166783 MIM:614593; AllianceGenome:HGNC:29562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LKAP; LMKB; PPP1R34; KIAA0430
    Summary
    This gene encodes a putative peroxisomal protein that appears to be conserved across Euteleostomi. In humans, it may be autoantigenic. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in lymph node (RPKM 15.3), ovary (RPKM 15.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MARF1 in Genome Data Viewer
    Location:
    16p13.11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (15594387..15643154, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (15599246..15648059, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15688244..15737011, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MPV17L-BMERB1 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr16:15506027-15506244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:15528749-15529371 Neighboring gene MPV17 mitochondrial inner membrane protein like Neighboring gene bMERB domain containing 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:15587399-15588598 Neighboring gene Sharpr-MPRA regulatory region 1380 Neighboring gene uncharacterized LOC105371102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15603978-15604478 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:15607777-15607948 Neighboring gene NANOG hESC enhancer GRCh37_chr16:15632973-15633474 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:15636050-15636595 Neighboring gene Sharpr-MPRA regulatory region 9672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15673003-15673503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:15680941-15681442 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:15684383-15685582 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:15693082-15694281 Neighboring gene Sharpr-MPRA regulatory region 10508 Neighboring gene uncharacterized LOC124903649 Neighboring gene microRNA 6506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15743803-15744304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15744305-15744804 Neighboring gene Sharpr-MPRA regulatory region 7034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:15766651-15767392 Neighboring gene microRNA 484 Neighboring gene Sharpr-MPRA regulatory region 12074 Neighboring gene nudE neurodevelopment protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15814393-15815196 Neighboring gene myosin heavy chain 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. P-bodies directly regulate MARF1-mediated mRNA decay in human cells. Brothers WR, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35801873, Free PMC Article
    2. A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. Brothers WR, et al. Elife, 2020 Jun 8. PMID 32510323, Free PMC Article
    3. Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Dunster K, et al. Clin Exp Immunol, 2005 Jun. PMID 15932519, Free PMC Article
    4. LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. Bloch DB, et al. PLoS One, 2014. PMID 24755989, Free PMC Article
    5. Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs. Nishimura T, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30364987, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P-bodies directly regulate MARF1-mediated mRNA decay in human cells.
      Title: P-bodies directly regulate MARF1-mediated mRNA decay in human cells.
    2. A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.
      Title: A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.
    3. Human MARF1 is an endoribonuclease that interacts with the DCP1:DCP2 decapping complex and degrades target mRNAs.
      Title: Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
    4. LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L.
      Title: LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiosis regulator and mRNA stability factor 1
    Names
    limkain-b1
    meiosis arrest female 1
    meiosis arrest female protein 1
    protein phosphatase 1, regulatory subunit 34

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021407.1 RefSeqGene

      Range
      5013..53780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184998.2 → NP_001171927.1  meiosis regulator and mRNA stability factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001171927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) differs in sequence but is the same length as isoform 1.
      Source sequence(s)
      AB007890, BC064914, BC144514, DB360504
      Consensus CDS
      CCDS53990.1
      UniProtKB/TrEMBL
      G8JLP4
      Related
      ENSP00000450309.1, ENST00000551742.5
      Conserved Domains (12) summary
      cd09977
      Location:876 → 937
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1004 → 1074
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1100 → 1171
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1176 → 1247
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1260 → 1330
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1336 → 1406
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1412 → 1484
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1487 → 1562
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:776 → 872
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:509 → 581
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:787 → 875
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    2. NM_001184999.2 → NP_001171928.1  meiosis regulator and mRNA stability factor 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AB007890, AC026401, BC064914, BC144515, DB360504
      Consensus CDS
      CCDS55991.1
      UniProtKB/TrEMBL
      G8JLP4
      Related
      ENSP00000449376.1, ENST00000548025.5
      Conserved Domains (12) summary
      cd09977
      Location:873 → 934
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1001 → 1071
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1097 → 1168
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1173 → 1244
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1257 → 1327
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1333 → 1403
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1409 → 1481
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1484 → 1559
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:349 → 491
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:773 → 869
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:507 → 579
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:784 → 872
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    3. NM_014647.4 → NP_055462.2  meiosis regulator and mRNA stability factor 1 isoform 1

      See identical proteins and their annotated locations for NP_055462.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AB007890, BC064914, BC137165, DB360504
      Consensus CDS
      CCDS10562.2
      UniProtKB/Swiss-Prot
      A8MSK2, B2RNX2, B4DYY9, B7ZMG1, B7ZMG2, F8VV09, Q6P1R6, Q8WYR2, Q9Y4F3, Q9Y4J9
      UniProtKB/TrEMBL
      G8JLP4
      Related
      ENSP00000379654.3, ENST00000396368.8
      Conserved Domains (12) summary
      cd09977
      Location:876 → 937
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1004 → 1074
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1100 → 1171
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1176 → 1247
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1260 → 1330
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1336 → 1406
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1412 → 1484
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1487 → 1562
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:776 → 872
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:510 → 582
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:787 → 875
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      15594387..15643154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434955.1 → XP_047290911.1  meiosis regulator and mRNA stability factor 1 isoform X22

      UniProtKB/TrEMBL
      G8JLP4

    2. XM_047434954.1 → XP_047290910.1  meiosis regulator and mRNA stability factor 1 isoform X21

      UniProtKB/TrEMBL
      G8JLP4

    3. XM_047434950.1 → XP_047290906.1  meiosis regulator and mRNA stability factor 1 isoform X17

      UniProtKB/TrEMBL
      G8JLP4

    4. XM_047434948.1 → XP_047290904.1  meiosis regulator and mRNA stability factor 1 isoform X15

      UniProtKB/TrEMBL
      G8JLP4

    5. XM_047434946.1 → XP_047290902.1  meiosis regulator and mRNA stability factor 1 isoform X13

      UniProtKB/TrEMBL
      G8JLP4

    6. XM_047434953.1 → XP_047290909.1  meiosis regulator and mRNA stability factor 1 isoform X20

      UniProtKB/TrEMBL
      G8JLP4

    7. XM_047434949.1 → XP_047290905.1  meiosis regulator and mRNA stability factor 1 isoform X16

      UniProtKB/TrEMBL
      G8JLP4

    8. XM_017023906.3 → XP_016879395.1  meiosis regulator and mRNA stability factor 1 isoform X14

      UniProtKB/TrEMBL
      G8JLP4

    9. XM_017023905.3 → XP_016879394.1  meiosis regulator and mRNA stability factor 1 isoform X12

      UniProtKB/TrEMBL
      G8JLP4

    10. XM_047434951.1 → XP_047290907.1  meiosis regulator and mRNA stability factor 1 isoform X18

      UniProtKB/TrEMBL
      G8JLP4

    11. XM_047434945.1 → XP_047290901.1  meiosis regulator and mRNA stability factor 1 isoform X11

      UniProtKB/TrEMBL
      G8JLP4
      Related
      ENSP00000439819.2, ENST00000540441.6

    12. XM_017023904.3 → XP_016879393.1  meiosis regulator and mRNA stability factor 1 isoform X10

      UniProtKB/TrEMBL
      G8JLP4

    13. XM_017023903.3 → XP_016879392.1  meiosis regulator and mRNA stability factor 1 isoform X9

      UniProtKB/TrEMBL
      G8JLP4

    14. XM_047434943.1 → XP_047290899.1  meiosis regulator and mRNA stability factor 1 isoform X8

      UniProtKB/TrEMBL
      G8JLP4

    15. XM_047434941.1 → XP_047290897.1  meiosis regulator and mRNA stability factor 1 isoform X6

      UniProtKB/TrEMBL
      G8JLP4

    16. XM_005255706.3 → XP_005255763.1  meiosis regulator and mRNA stability factor 1 isoform X4

      See identical proteins and their annotated locations for XP_005255763.1

      UniProtKB/TrEMBL
      G8JLP4
      Conserved Domains (12) summary
      cd09977
      Location:875 → 936
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1003 → 1073
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1099 → 1170
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1175 → 1246
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1259 → 1329
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1335 → 1405
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1411 → 1483
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1486 → 1561
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:775 → 871
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:509 → 581
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:786 → 874
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    17. XM_017023902.3 → XP_016879391.1  meiosis regulator and mRNA stability factor 1 isoform X7

      UniProtKB/TrEMBL
      G8JLP4

    18. XM_005255707.3 → XP_005255764.1  meiosis regulator and mRNA stability factor 1 isoform X5

      See identical proteins and their annotated locations for XP_005255764.1

      UniProtKB/TrEMBL
      G8JLP4
      Conserved Domains (11) summary
      cd09977
      Location:867 → 928
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:995 → 1065
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1091 → 1162
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1167 → 1238
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1251 → 1321
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1327 → 1397
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1403 → 1475
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1478 → 1553
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:510 → 582
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:778 → 866
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    19. XM_005255704.2 → XP_005255761.1  meiosis regulator and mRNA stability factor 1 isoform X1

      See identical proteins and their annotated locations for XP_005255761.1

      UniProtKB/TrEMBL
      G8JLP4
      Conserved Domains (12) summary
      cd09977
      Location:877 → 938
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1005 → 1075
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1101 → 1172
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1177 → 1248
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1261 → 1331
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1337 → 1407
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1413 → 1485
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1488 → 1563
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:777 → 873
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:510 → 582
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:788 → 876
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    20. XM_047434947.1 → XP_047290903.1  meiosis regulator and mRNA stability factor 1 isoform X14

      UniProtKB/TrEMBL
      G8JLP4

    21. XM_047434944.1 → XP_047290900.1  meiosis regulator and mRNA stability factor 1 isoform X8

      UniProtKB/TrEMBL
      G8JLP4

    22. XM_047434942.1 → XP_047290898.1  meiosis regulator and mRNA stability factor 1 isoform X6

      UniProtKB/TrEMBL
      G8JLP4

    23. XM_047434939.1 → XP_047290895.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      G8JLP4

    24. XM_017023901.3 → XP_016879390.1  meiosis regulator and mRNA stability factor 1 isoform X3

      UniProtKB/TrEMBL
      G8JLP4
      Conserved Domains (12) summary
      cd09977
      Location:876 → 937
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1004 → 1074
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1100 → 1171
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1176 → 1247
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1260 → 1330
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1336 → 1406
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1412 → 1484
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1487 → 1562
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:776 → 872
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:509 → 581
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:787 → 875
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    25. XM_047434940.1 → XP_047290896.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      G8JLP4

    26. XM_047434938.1 → XP_047290894.1  meiosis regulator and mRNA stability factor 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MSK2, B2RNX2, B4DYY9, B7ZMG1, B7ZMG2, F8VV09, Q6P1R6, Q8WYR2, Q9Y4F3, Q9Y4J9
      UniProtKB/TrEMBL
      G8JLP4

    27. XM_017023900.3 → XP_016879389.1  meiosis regulator and mRNA stability factor 1 isoform X1

      UniProtKB/TrEMBL
      G8JLP4
      Conserved Domains (12) summary
      cd09977
      Location:877 → 938
      LOTUS_1_Limkain_b1; The first LOTUS domain on Limkain b1(LKAP)
      cd09978
      Location:1005 → 1075
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1101 → 1172
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1177 → 1248
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1261 → 1331
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09982
      Location:1337 → 1407
      LOTUS_6_Limkain_b1; The sixth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1413 → 1485
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1488 → 1563
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:352 → 494
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      COG0724
      Location:777 → 873
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12255
      Location:510 → 582
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:788 → 876
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

    28. XM_047434952.1 → XP_047290908.1  meiosis regulator and mRNA stability factor 1 isoform X19

      UniProtKB/TrEMBL
      G8JLP4

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1252378..1301165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329172.1 → XP_054185147.1  meiosis regulator and mRNA stability factor 1 isoform X22

      UniProtKB/TrEMBL
      G8JLP4

    2. XM_054329171.1 → XP_054185146.1  meiosis regulator and mRNA stability factor 1 isoform X21

      UniProtKB/TrEMBL
      G8JLP4

    3. XM_054329166.1 → XP_054185141.1  meiosis regulator and mRNA stability factor 1 isoform X17

      UniProtKB/TrEMBL
      G8JLP4

    4. XM_054329164.1 → XP_054185139.1  meiosis regulator and mRNA stability factor 1 isoform X15

      UniProtKB/TrEMBL
      G8JLP4

    5. XM_054329162.1 → XP_054185137.1  meiosis regulator and mRNA stability factor 1 isoform X13

      UniProtKB/TrEMBL
      G8JLP4

    6. XM_054329170.1 → XP_054185145.1  meiosis regulator and mRNA stability factor 1 isoform X20

      UniProtKB/TrEMBL
      G8JLP4

    7. XM_054329165.1 → XP_054185140.1  meiosis regulator and mRNA stability factor 1 isoform X16

      UniProtKB/TrEMBL
      G8JLP4

    8. XM_054329161.1 → XP_054185136.1  meiosis regulator and mRNA stability factor 1 isoform X14

      UniProtKB/TrEMBL
      G8JLP4

    9. XM_054329159.1 → XP_054185134.1  meiosis regulator and mRNA stability factor 1 isoform X12

      UniProtKB/TrEMBL
      G8JLP4

    10. XM_054329167.1 → XP_054185142.1  meiosis regulator and mRNA stability factor 1 isoform X18

      UniProtKB/TrEMBL
      G8JLP4

    11. XM_054329158.1 → XP_054185133.1  meiosis regulator and mRNA stability factor 1 isoform X11

      UniProtKB/TrEMBL
      G8JLP4

    12. XM_054329157.1 → XP_054185132.1  meiosis regulator and mRNA stability factor 1 isoform X10

      UniProtKB/TrEMBL
      G8JLP4

    13. XM_054329156.1 → XP_054185131.1  meiosis regulator and mRNA stability factor 1 isoform X9

      UniProtKB/TrEMBL
      G8JLP4

    14. XM_054329154.1 → XP_054185129.1  meiosis regulator and mRNA stability factor 1 isoform X8

      UniProtKB/TrEMBL
      G8JLP4

    15. XM_054329151.1 → XP_054185126.1  meiosis regulator and mRNA stability factor 1 isoform X6

      UniProtKB/TrEMBL
      G8JLP4

    16. XM_054329147.1 → XP_054185122.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      G8JLP4

    17. XM_054329153.1 → XP_054185128.1  meiosis regulator and mRNA stability factor 1 isoform X7

      UniProtKB/TrEMBL
      G8JLP4

    18. XM_054329149.1 → XP_054185124.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      G8JLP4

    19. XM_054329143.1 → XP_054185118.1  meiosis regulator and mRNA stability factor 1 isoform X1

      UniProtKB/TrEMBL
      G8JLP4

    20. XM_054329144.1 → XP_054185119.1  meiosis regulator and mRNA stability factor 1 isoform X1

      UniProtKB/TrEMBL
      G8JLP4

    21. XM_054329152.1 → XP_054185127.1  meiosis regulator and mRNA stability factor 1 isoform X6

      UniProtKB/TrEMBL
      G8JLP4

    22. XM_054329146.1 → XP_054185121.1  meiosis regulator and mRNA stability factor 1 isoform X3

      UniProtKB/TrEMBL
      G8JLP4

    23. XM_054329145.1 → XP_054185120.1  meiosis regulator and mRNA stability factor 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MSK2, B2RNX2, B4DYY9, B7ZMG1, B7ZMG2, F8VV09, Q6P1R6, Q8WYR2, Q9Y4F3, Q9Y4J9
      UniProtKB/TrEMBL
      G8JLP4

    24. XM_054329148.1 → XP_054185123.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      G8JLP4

    25. XM_054329150.1 → XP_054185125.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      G8JLP4

    26. XM_054329168.1 → XP_054185143.1  meiosis regulator and mRNA stability factor 1 isoform X18

      UniProtKB/TrEMBL
      G8JLP4

    27. XM_054329155.1 → XP_054185130.1  meiosis regulator and mRNA stability factor 1 isoform X8

      UniProtKB/TrEMBL
      G8JLP4

    28. XM_054329163.1 → XP_054185138.1  meiosis regulator and mRNA stability factor 1 isoform X14

      UniProtKB/TrEMBL
      G8JLP4

    29. XM_054329160.1 → XP_054185135.1  meiosis regulator and mRNA stability factor 1 isoform X13

      UniProtKB/TrEMBL
      G8JLP4

    30. XM_054329169.1 → XP_054185144.1  meiosis regulator and mRNA stability factor 1 isoform X19

      UniProtKB/TrEMBL
      G8JLP4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      15599246..15648059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314483.1 → XP_054170458.1  meiosis regulator and mRNA stability factor 1 isoform X22

      UniProtKB/TrEMBL
      G8JLP4

    2. XM_054314482.1 → XP_054170457.1  meiosis regulator and mRNA stability factor 1 isoform X21

      UniProtKB/TrEMBL
      G8JLP4

    3. XM_054314477.1 → XP_054170452.1  meiosis regulator and mRNA stability factor 1 isoform X17

      UniProtKB/TrEMBL
      G8JLP4

    4. XM_054314475.1 → XP_054170450.1  meiosis regulator and mRNA stability factor 1 isoform X15

      UniProtKB/TrEMBL
      G8JLP4

    5. XM_054314473.1 → XP_054170448.1  meiosis regulator and mRNA stability factor 1 isoform X13

      UniProtKB/TrEMBL
      G8JLP4

    6. XM_054314481.1 → XP_054170456.1  meiosis regulator and mRNA stability factor 1 isoform X20

      UniProtKB/TrEMBL
      G8JLP4

    7. XM_054314476.1 → XP_054170451.1  meiosis regulator and mRNA stability factor 1 isoform X16

      UniProtKB/TrEMBL
      G8JLP4

    8. XM_054314472.1 → XP_054170447.1  meiosis regulator and mRNA stability factor 1 isoform X14

      UniProtKB/TrEMBL
      G8JLP4

    9. XM_054314470.1 → XP_054170445.1  meiosis regulator and mRNA stability factor 1 isoform X12

      UniProtKB/TrEMBL
      G8JLP4

    10. XM_054314478.1 → XP_054170453.1  meiosis regulator and mRNA stability factor 1 isoform X18

      UniProtKB/TrEMBL
      G8JLP4

    11. XM_054314469.1 → XP_054170444.1  meiosis regulator and mRNA stability factor 1 isoform X11

      UniProtKB/TrEMBL
      G8JLP4

    12. XM_054314468.1 → XP_054170443.1  meiosis regulator and mRNA stability factor 1 isoform X10

      UniProtKB/TrEMBL
      G8JLP4

    13. XM_054314467.1 → XP_054170442.1  meiosis regulator and mRNA stability factor 1 isoform X9

      UniProtKB/TrEMBL
      G8JLP4

    14. XM_054314465.1 → XP_054170440.1  meiosis regulator and mRNA stability factor 1 isoform X8

      UniProtKB/TrEMBL
      G8JLP4

    15. XM_054314462.1 → XP_054170437.1  meiosis regulator and mRNA stability factor 1 isoform X6

      UniProtKB/TrEMBL
      G8JLP4

    16. XM_054314458.1 → XP_054170433.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      G8JLP4

    17. XM_054314464.1 → XP_054170439.1  meiosis regulator and mRNA stability factor 1 isoform X7

      UniProtKB/TrEMBL
      G8JLP4

    18. XM_054314460.1 → XP_054170435.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      G8JLP4

    19. XM_054314454.1 → XP_054170429.1  meiosis regulator and mRNA stability factor 1 isoform X1

      UniProtKB/TrEMBL
      G8JLP4

    20. XM_054314455.1 → XP_054170430.1  meiosis regulator and mRNA stability factor 1 isoform X1

      UniProtKB/TrEMBL
      G8JLP4

    21. XM_054314463.1 → XP_054170438.1  meiosis regulator and mRNA stability factor 1 isoform X6

      UniProtKB/TrEMBL
      G8JLP4

    22. XM_054314457.1 → XP_054170432.1  meiosis regulator and mRNA stability factor 1 isoform X3

      UniProtKB/TrEMBL
      G8JLP4

    23. XM_054314456.1 → XP_054170431.1  meiosis regulator and mRNA stability factor 1 isoform X2

      UniProtKB/TrEMBL
      G8JLP4

    24. XM_054314459.1 → XP_054170434.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      G8JLP4

    25. XM_054314461.1 → XP_054170436.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      G8JLP4

    26. XM_054314479.1 → XP_054170454.1  meiosis regulator and mRNA stability factor 1 isoform X18

      UniProtKB/TrEMBL
      G8JLP4

    27. XM_054314466.1 → XP_054170441.1  meiosis regulator and mRNA stability factor 1 isoform X8

      UniProtKB/TrEMBL
      G8JLP4

    28. XM_054314474.1 → XP_054170449.1  meiosis regulator and mRNA stability factor 1 isoform X14

      UniProtKB/TrEMBL
      G8JLP4

    29. XM_054314471.1 → XP_054170446.1  meiosis regulator and mRNA stability factor 1 isoform X13

      UniProtKB/TrEMBL
      G8JLP4

    30. XM_054314480.1 → XP_054170455.1  meiosis regulator and mRNA stability factor 1 isoform X19

      UniProtKB/TrEMBL
      G8JLP4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019081.2: Suppressed sequence

      Description
      NM_019081.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y4F3.6 GenPept UniProtKB/Swiss-Prot:Q9Y4F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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