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    Mettl9 methyltransferase 9, His-X-His N1(pi)-histidine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100302453, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mettl9provided by RGD
    Official Full Name
    methyltransferase 9, His-X-His N1(pi)-histidineprovided by RGD
    Primary source
    RGD:2311609
    See related
    EnsemblRapid:ENSRNOG00000025940 AllianceGenome:RGD:2311609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-L-histidine N-pros-methyltransferase activity. Predicted to be active in endoplasmic reticulum and mitochondrion. Orthologous to human METTL9 (methyltransferase 9, His-X-His N1(pi)-histidine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 157.9), Adrenal (RPKM 123.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl9 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (185006953..185054359)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175575805..175623065)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (190962935..191009926)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene U6 spliceosomal RNA Neighboring gene immunoglobulin superfamily, member 6 Neighboring gene otoancorin Neighboring gene uncharacterized LOC108349630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. Huang C, et al. J Neuroinflammation, 2023 Feb 17. PMID 36803376, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.
      Title: Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-L-histidine N-pros-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-L-histidine N-pros-methyltransferase
    Names
    methyltransferase 9, His-X-His N1-histidine
    methyltransferase like 9
    methyltransferase-like protein 9
    NP_001156636.1
    XP_006230216.1
    XP_008757880.1
    XP_008757881.1
    XP_063140139.1
    XP_063140378.1
    XP_063140645.1
    XP_063140947.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163164.1 → NP_001156636.1  protein-L-histidine N-pros-methyltransferase

      See identical proteins and their annotated locations for NP_001156636.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I8T8, G0Z7P9
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 317
      DREV; DREV methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      185006953..185054359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759659.4 → XP_008757881.1  protein-L-histidine N-pros-methyltransferase isoform X3

      UniProtKB/TrEMBL
      G0Z7P9
      Conserved Domains (1) summary
      pfam05219
      Location:16 → 277
      DREV; DREV methyltransferase

    2. XM_063284069.1 → XP_063140139.1  protein-L-histidine N-pros-methyltransferase isoform X4

      UniProtKB/TrEMBL
      G0Z7P9

    3. XM_006230154.4 → XP_006230216.1  protein-L-histidine N-pros-methyltransferase isoform X1

      UniProtKB/TrEMBL
      G0Z7P9
      Related
      ENSRNOP00000037064.4, ENSRNOT00000039186.5
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 316
      DREV; DREV methyltransferase

    4. XM_063284308.1 → XP_063140378.1  protein-L-histidine N-pros-methyltransferase isoform X5

    5. XM_063284877.1 → XP_063140947.1  protein-L-histidine N-pros-methyltransferase isoform X7

    6. XM_008759658.3 → XP_008757880.1  protein-L-histidine N-pros-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A6I8T9
      Related
      ENSRNOP00000102286.1, ENSRNOT00000141315.1
      Conserved Domains (1) summary
      cl17173
      Location:56 → 251
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_063284575.1 → XP_063140645.1  protein-L-histidine N-pros-methyltransferase isoform X6

      UniProtKB/TrEMBL
      C3VPW1
    Nucleotide Protein Strain
    Heading Accession and Version

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