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    Tbc1d22b TBC1 domain family, member 22B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502414, updated on 27-Dec-2024

    Summary

    Official Symbol
    Tbc1d22bprovided by RGD
    Official Full Name
    TBC1 domain family, member 22Bprovided by RGD
    Primary source
    RGD:1564987
    See related
    EnsemblRapid:ENSRNOG00000059458 AllianceGenome:RGD:1564987
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 14-3-3 protein binding activity and GTPase activator activity. Predicted to be active in Golgi apparatus. Orthologous to human TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 43.5), Spleen (RPKM 41.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tbc1d22b in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7620716..7676809)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7619096..7675232)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (8216097..8278344)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RAN, member RAS oncogene family, pseudogene 5 Neighboring gene transmembrane protein 217B Neighboring gene transmembrane protein 217 Neighboring gene ring finger protein 8 Neighboring gene cap methyltransferase 1 Neighboring gene coiled-coil domain containing 167

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 22B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025059.1NP_001020230.1  TBC1 domain family member 22B

      See identical proteins and their annotated locations for NP_001020230.1

      Status: PROVISIONAL

      Source sequence(s)
      AY380821
      UniProtKB/TrEMBL
      A0A8I5ZVI8, A0A8I5ZW76, A6JJV3, Q6U1J1
      Related
      ENSRNOP00000083239.1, ENSRNOT00000093855.2
      Conserved Domains (1) summary
      smart00164
      Location:207457
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7620716..7676809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005497331.2 RNA Sequence