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    Tagap T-cell activation RhoGTPase activating protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308097, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tagapprovided by RGD
    Official Full Name
    T-cell activation RhoGTPase activating proteinprovided by RGD
    Primary source
    RGD:1308618
    See related
    EnsemblRapid:ENSRNOG00000018915 AllianceGenome:RGD:1308618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction. Predicted to act upstream of or within defense response to virus. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 79.8), Uterus (RPKM 77.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tagap in Genome Data Viewer
    Location:
    1q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49575750..49584747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47170725..47179705, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47493990..47503492, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 546 Neighboring gene radial spoke head 3 Neighboring gene uncharacterized LOC120099118 Neighboring gene uncharacterized LOC102551987

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development. Sun HG, et al. Clin Exp Immunol, 2023 Dec 11. PMID 37458218, Free PMC Article
    2. An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. Liao J, et al. PLoS One, 2014. PMID 25268627, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
      Title: TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell activation Rho GTPase-activating protein
    Names
    T-cell activation GTPase activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309449.1 → NP_001296378.1  T-cell activation Rho GTPase-activating protein

      See identical proteins and their annotated locations for NP_001296378.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A128DYU5, A6KP20, D3ZXG5
      Conserved Domains (1) summary
      cd04402
      Location:85 → 281
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49575750..49584747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003748695.6 → XP_003748743.1  T-cell activation Rho GTPase-activating protein isoform X1

      See identical proteins and their annotated locations for XP_003748743.1

      UniProtKB/TrEMBL
      A0A128DYU5, A6KP20, D3ZXG5
      Conserved Domains (1) summary
      cd04402
      Location:85 → 281
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

    2. XM_006227912.5 → XP_006227974.1  T-cell activation Rho GTPase-activating protein isoform X2

      See identical proteins and their annotated locations for XP_006227974.1

      UniProtKB/TrEMBL
      A0A128DYU5
      Related
      ENSRNOP00000025580.7, ENSRNOT00000025580.9
      Conserved Domains (1) summary
      cd04402
      Location:79 → 275
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107455.1: Suppressed sequence

      Description
      NM_001107455.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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