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    Amotl2 angiomotin like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amotl2provided by RGD
    Official Full Name
    angiomotin like 2provided by RGD
    Primary source
    RGD:70977
    See related
    EnsemblRapid:ENSRNOG00000008487 AllianceGenome:RGD:70977
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lccp
    Summary
    Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in several processes, including endothelial cell morphogenesis; establishment of cell polarity involved in ameboidal cell migration; and hippo signaling. Predicted to be located in several cellular components, including apical plasma membrane; cell junction; and podosome. Predicted to be active in bicellular tight junction; cytoplasmic vesicle; and plasma membrane. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 426.0), Kidney (RPKM 294.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amotl2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112182060..112198032)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103303368..103319161)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111210261..111226217)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene uncharacterized LOC134480096 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene receptor-like tyrosine kinase Neighboring gene uncharacterized LOC102549824

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling. Deng J, et al. J Cardiovasc Pharmacol, 2024 Sep 1. PMID 39027975
    2. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Patrie KM. Biochim Biophys Acta, 2005 Aug 15. PMID 16019084
    3. Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Bratt A, et al. Gene, 2002 Sep 18. PMID 12406577
    4. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Sugihara-Mizuno Y, et al. Genes Cells, 2007 Apr. PMID 17397395
    5. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Zhao B, et al. Genes Dev, 2011 Jan 1. PMID 21205866, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.
      Title: Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of cell polarity involved in ameboidal cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    angiomotin-like protein 2
    Names
    Leman coiled-coil protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031717.1 → NP_113905.1  angiomotin-like protein 2

      See identical proteins and their annotated locations for NP_113905.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/Swiss-Prot
      G3V735
      UniProtKB/TrEMBL
      A0A0G2KAV3
      Related
      ENSRNOP00000075540.2, ENSRNOT00000090221.3
      Conserved Domains (2) summary
      COG1196
      Location:300 → 577
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:477 → 679
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112182060..112198032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243680.5 → XP_006243742.1  angiomotin-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAV3, A0A8I6AGR3
      Related
      ENSRNOP00000093935.1, ENSRNOT00000094404.2
      Conserved Domains (1) summary
      pfam12240
      Location:500 → 701
      Angiomotin_C; Angiomotin C terminal

    2. XM_039082102.2 → XP_038938030.1  angiomotin-like protein 2 isoform X2

      UniProtKB/Swiss-Prot
      G3V735
      UniProtKB/TrEMBL
      A0A0G2KAV3
      Conserved Domains (2) summary
      COG1196
      Location:300 → 577
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:477 → 679
      Angiomotin_C; Angiomotin C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V735.1 GenPept UniProtKB/Swiss-Prot:G3V735

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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