Agtrap angiotensin II receptor-associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agtrapprovided by RGD
Official Full Name: angiotensin II receptor-associated proteinprovided by RGD
Primary source: RGD:1359346
See related: EnsemblRapid:ENSRNOG00000008619 AllianceGenome:RGD:1359346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable angiotensin type II receptor activity and identical protein binding activity. Involved in response to hypoxia. Predicted to be located in Golgi apparatus and cell cortex. Predicted to be active in plasma membrane. Biomarker of hypertension. Orthologous to human AGTRAP (angiotensin II receptor associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 115.0), Adrenal (RPKM 29.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (163790565..163802174, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (158507427..158519036, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (164888069..164898387, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancement of angiotensin II type 1 receptor-associated protein in the paraventricular nucleus suppresses angiotensin II-dependent hypertension.
Title: Enhancement of angiotensin II type 1 receptor-associated protein in the paraventricular nucleus suppresses angiotensin II-dependent hypertension.
A single dose of angiotensin(17) at the same concentration as angiotensin II induced Agtrap gene expression.
Title: Angiotensin II type 1 receptor-associated protein plays a role in regulating the local renin-angiotensin system in HSC-T6 cells.
The expression of both angiotensin AGTRa and AGTR2 receptors was increased in the myocardium of overfed rats, and ischemia-reperfusion increased the expression of both receptors in control rats but reduced it in overfed rats.
Title: Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors.
AT(1)-AB induces Ang II sensitivity. Our mechanistic study supports the existence of an "autoimmune-activating receptor" that could contribute to Ang II sensitivity and possible to preeclampsia.
Title: Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats.
results suggest that the local renin-angiotensin system is activated in diabetic skin and Angiotensin II receptors type 1 and 2 are likely to mediate the pathological changes of diabetic skin
Title: Activation of skin renin-angiotensin system in diabetic rats.
These results show that adipocyte-derived angiotensin II is critically involved in perivascular adipose tissue-mediated potentiation of vasoconstriction in mesenteric arteries.
Title: Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: the role of adipocyte-derived angiotensin II.
Long-term selective Ang II blockade ameliorates insulin resistance in adipose tissue from a model of metabolic syndrome.
Title: Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats.
Angiotensin II distinctly upregulated TLR4 expression in the cells.
Title: Angiotensin II induces inflammatory response partly via toll-like receptor 4-dependent signaling pathway in vascular smooth muscle cells.
The growth inhibitory effects of ATRAP might be due to interfering with angiotensin 1 receptor activation in vascular smooth muscle cell growth.
Title: Inhibitory effect of angiotensin II type 1 receptor-associated protein on vascular smooth muscle cell growth and neointimal formation.
ATRAP promotes internalization of AT1R and attenuates the angiotensin II-mediated c-fos-transforming growth factor-beta pathway and proliferative response in vascular smooth muscle cells, suggesting a strategy to inhibit vascular fibrosis and remodeling
Title: Novel regulatory effect of angiotensin II type 1 receptor-interacting molecule on vascular smooth muscle cells.

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General gene information

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Markers

RH140310 (e-PCR)
- UniSTS:222387

RH142367 (e-PCR)
- UniSTS:231614

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables angiotensin type II receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: type-1 angiotensin II receptor-associated protein

Names: AT1 receptor-associated protein; angiotensin II, type I receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007654.1 → NP_001007655.1 type-1 angiotensin II receptor-associated protein

See identical proteins and their annotated locations for NP_001007655.1

Status: PROVISIONAL

Source sequence(s)

BC082019

UniProtKB/Swiss-Prot

Q642A2

UniProtKB/TrEMBL

A0A8I5ZTN3, A6IU47

Related

ENSRNOP00000011747.3, ENSRNOT00000011747.8

Conserved Domains (1) summary

smart00805
Location:1 → 160

AGTRAP; Angiotensin II, type I receptor-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

163790565..163802174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109696.2 → XP_038965624.1 type-1 angiotensin II receptor-associated protein isoform X1

Conserved Domains (1) summary

cl05741
Location:1 → 97

AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)