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    Rdh5 retinol dehydrogenase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rdh5provided by RGD
    Official Full Name
    retinol dehydrogenase 5provided by RGD
    Primary source
    RGD:1308849
    See related
    EnsemblRapid:ENSRNOG00000007784 AllianceGenome:RGD:1308849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rdh1
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity; protein homodimerization activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in retinoid metabolic process and steroid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 61.3), Liver (RPKM 61.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rdh5 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1912120..1931836, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1341172..1346863, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3335681..3342573, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene growth differentiation factor 11 Neighboring gene Cd63 molecule Neighboring gene uncharacterized LOC120093529 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus. Lidén M, et al. J Biol Chem, 2001 Dec 28. PMID 11675386
    2. The N-terminus of retinol dehydrogenase type 1 signals cytosolic orientation in the microsomal membrane. Wang J, et al. Biochemistry, 2001 Oct 23. PMID 11601977
    3. Gene structure, expression analysis, and membrane topology of RDH4. Romert A, et al. Exp Cell Res, 2000 Apr 10. PMID 10739682
    4. 11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus. Gonzalez-Fernandez F, et al. Mol Vis, 1999 Dec 30. PMID 10617778
    5. Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue. Wang J, et al. Biochem J, 1999 Feb 15. PMID 9931293, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 5
    Names
    11-cis retinol dehydrogenase
    9-cis-retinol dehydrogenase
    retinol dehydrogenase 1 (11-cis)
    retinol dehydrogenase 5 (11-cis/9-cis)
    retinol dehydrogenase type 5
    NP_001385693.1
    NP_001385694.1
    NP_001385695.1
    XP_063120086.1
    XP_063120087.1
    XP_063120088.1
    XP_063120089.1
    XP_063120090.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398764.1 → NP_001385693.1  retinol dehydrogenase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K1R4
      Related
      ENSRNOP00000071951.2, ENSRNOT00000081756.3
      Conserved Domains (1) summary
      cl21454
      Location:31 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001398765.1 → NP_001385694.1  retinol dehydrogenase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K1R4
      Conserved Domains (1) summary
      cl21454
      Location:31 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001398766.1 → NP_001385695.1  retinol dehydrogenase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K1R4
      Conserved Domains (1) summary
      cl21454
      Location:31 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1912120..1931836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264019.1 → XP_063120089.1  retinol dehydrogenase 5 isoform X1

    2. XM_063264018.1 → XP_063120088.1  retinol dehydrogenase 5 isoform X1

    3. XM_063264017.1 → XP_063120087.1  retinol dehydrogenase 5 isoform X1

    4. XM_063264016.1 → XP_063120086.1  retinol dehydrogenase 5 isoform X1

    5. XM_063264020.1 → XP_063120090.1  retinol dehydrogenase 5 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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