Uck1 uridine-cytidine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uck1provided by RGD
Official Full Name: uridine-cytidine kinase 1provided by RGD
Primary source: RGD:1308313
See related: EnsemblRapid:ENSRNOG00000011467 AllianceGenome:RGD:1308313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytidine kinase activity and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to act upstream of or within UMP biosynthetic process. Predicted to be active in cytoplasm. Biomarker of nerve compression syndrome. Orthologous to human UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 138.7), Thymus (RPKM 132.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (35936328..35942213, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15538580..15544465, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (11271874..11277757, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Umpk (e-PCR), detects polymorphism
- UniSTS:144729

RH138730 (e-PCR)
- UniSTS:220817

RH130122 (e-PCR)
- UniSTS:213410

RH131674 (e-PCR)
- UniSTS:214957

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables uridine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	ISO Inferred from Sequence Orthology more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uridine-cytidine kinase 1

NP_001101301.2

EC 2.7.1.48

XP_063140034.1

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107831.4 → NP_001101301.2 uridine-cytidine kinase 1

See identical proteins and their annotated locations for NP_001101301.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JU46, B5DF24

Related

ENSRNOP00000015792.6, ENSRNOT00000015792.9

Conserved Domains (1) summary

cd02023
Location:31 → 236

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...