Arhgdia Rho GDP dissociation inhibitor alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgdiaprovided by RGD
Official Full Name: Rho GDP dissociation inhibitor alphaprovided by RGD
Primary source: RGD:1359547
See related: AllianceGenome:RGD:1359547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bles01; Rho GDI 1
Summary: Enables Hsp90 protein binding activity; enzyme binding activity; and fatty acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to redox state; and regulation of cell shape. Located in extracellular space. Is active in synapse. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 669.8), Thymus (RPKM 641.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106352858..106356347, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105854526..105858020, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109754012..109757506, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A direct interaction between RhoGDIalpha/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.
Title: A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.
Rho GDP dissociation inhibitor alpha silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling
Title: Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling.
Results show that RhoGDIalpha is transcriptionally regulated by ATF4 in neurons and that RhoGDIalpha knockown reduces Cdc42 expression supporting the view that RhoGDIalpha mediates the effects of ATF4 on Cdc42 and therefore on mushroom spines and excitatory synapses.
Title: Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα.
The siRNA-mediated suppression of expression of alphaGDI especially affected vesicle dynamics.
Title: Impaired αGDI Function in the X-Linked Intellectual Disability: The Impact on Astroglia Vesicle Dynamics.
eIF5A1 upregulates RhoGDIalpha to promote neuroplasticity caudal to the spinal cord injury and functional recovery after spinal cord injury.
Title: eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach.
The regulatory functions of RhoGDIalpha were investigated by siRNA knockdown of RhoGDIalpha expression. After silencing RhoGDIalpha, the neuroprotective effects of senegenin on H/R-induced PC12 cell apoptosis were absent.
Title: Senegenin Inhibits Hypoxia/Reoxygenation-Induced Neuronal Apoptosis by Upregulating RhoGDIα.
RhoGDalpha controls ENaC expression and activity via Rac1.
Title: Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption.
Suggest that interaction between PRMT3 and RhoGDI-alpha mediates mycophenolic acid-induced pancreatic beta-cell death.
Title: PRMT3: new binding molecule to RhoGDI-α during mycophenolic acid-induced β-cell death.
the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation.
Title: TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.
analysis of regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIalpha
Title: Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIα.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables Rho GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to redox state	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho GDP-dissociation inhibitor 1

Names: Rho GDP dissociation inhibitor (GDI) alpha; rho-GDI alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007005.1 → NP_001007006.1 rho GDP-dissociation inhibitor 1

See identical proteins and their annotated locations for NP_001007006.1

Status: PROVISIONAL

Source sequence(s)

BC083817

UniProtKB/Swiss-Prot

Q5XI73

UniProtKB/TrEMBL

A6HLF5

Conserved Domains (1) summary

pfam02115
Location:11 → 201

Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

106352858..106356347 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247897.5 → XP_006247959.1 rho GDP-dissociation inhibitor 1 isoform X1

See identical proteins and their annotated locations for XP_006247959.1

UniProtKB/Swiss-Prot

Q5XI73

UniProtKB/TrEMBL

A6HLF5

Conserved Domains (1) summary

pfam02115
Location:11 → 201

Rho_GDI; RHO protein GDP dissociation inhibitor
XM_006247898.4 → XP_006247960.1 rho GDP-dissociation inhibitor 1 isoform X1

See identical proteins and their annotated locations for XP_006247960.1

UniProtKB/Swiss-Prot

Q5XI73

UniProtKB/TrEMBL

A6HLF5

Conserved Domains (1) summary

pfam02115
Location:11 → 201

Rho_GDI; RHO protein GDP dissociation inhibitor