Selenop selenoprotein P [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Selenopprovided by MGI
Official Full Name: selenoprotein Pprovided by MGI
Primary source: MGI:MGI:894288
See related: Ensembl:ENSMUSG00000064373 AllianceGenome:MGI:894288
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Se-P; selp; Sepp1; D15Ucla1
Summary: This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]
Expression: Broad expression in liver E18 (RPKM 1163.6), liver adult (RPKM 814.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 1.84 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (3300249..3309992)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (3270767..3280510)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet.
Title: Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet.
SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
Title: SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases.
Title: Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases.
Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.
Title: Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.
Role of selenoprotein P expression in the function of pancreatic beta cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
Title: Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
Title: Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
Selenoprotein P promotes the development of pulmonary hypertension by stimulating excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells.
Title: Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.
In this study, the role of SeP in ischemia/reperfusion (I/R) injury has been investigated.
Title: Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice.
Results indicate a diversity of RNA elements conducting multiple occurrences of UGA redefinition to control the synthesis of full-length and truncated selenoprotein P (SELENOP) isoforms.
Title: Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.
Study suggests the 3' UTR structural elements (SECIS) in Sepp1 functions with site specificity and further illustrates how mRNA processing may produce transcripts with altered coding potential to produce diversity in selenoprotein isoforms.
Title: Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables selenium binding	IBA Inferred from Biological aspect of Ancestor more info
enables selenium binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to selenium ion	IEA Inferred from Electronic Annotation more info
involved_in selenium compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within selenium compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within selenium compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: selenoprotein P

Names: plasma selenoprotein P; seP; selenoprotein P, plasma, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042613.2 → NP_001036078.1 selenoprotein P precursor

See identical proteins and their annotated locations for NP_001036078.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Variant Sepp1b is specifically localized to the hippocampus in the brain, and is a specific target for regulation by miR-7 microRNA (PMID:23064117).

Source sequence(s)

AA153204, AK002450, CK627189

Consensus CDS

CCDS27357.1

UniProtKB/Swiss-Prot

P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7

Related

ENSMUSP00000081004.6, ENSMUST00000082424.12

Conserved Domains (2) summary

pfam04592
Location:23 → 241

SelP_N; Selenoprotein P, N terminal region

pfam04593
Location:256 → 380

SelP_C; Selenoprotein P, C terminal region
NM_001042614.2 → NP_001036079.1 selenoprotein P precursor

See identical proteins and their annotated locations for NP_001036079.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as Sepp1c) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.

Source sequence(s)

AA153204, AI892015, AK002450

Consensus CDS

CCDS27357.1

UniProtKB/Swiss-Prot

P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7

Conserved Domains (2) summary

pfam04592
Location:23 → 241

SelP_N; Selenoprotein P, N terminal region

pfam04593
Location:256 → 380

SelP_C; Selenoprotein P, C terminal region
NM_009155.4 → NP_033181.3 selenoprotein P precursor

See identical proteins and their annotated locations for NP_033181.3

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.

Source sequence(s)

AA153204, AK002450, CB231357

Consensus CDS

CCDS27357.1

UniProtKB/Swiss-Prot

P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7

Related

ENSMUSP00000124305.3, ENSMUST00000159216.10

Conserved Domains (2) summary

pfam04592
Location:23 → 241

SelP_N; Selenoprotein P, N terminal region

pfam04593
Location:256 → 380

SelP_C; Selenoprotein P, C terminal region