Mia3 MIA SH3 domain ER export factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mia3provided by MGI
Official Full Name: MIA SH3 domain ER export factor 3provided by MGI
Primary source: MGI:MGI:2443183
See related: Ensembl:ENSMUSG00000056050 AllianceGenome:MGI:2443183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tango; Gm1525; TANGO1; 9130229H14Rik; A930039G15Rik; B230399H06Rik
Summary: Predicted to enable cargo receptor activity. Acts upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Located in endoplasmic reticulum membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart; nervous system; and nose. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 13.7), colon adult (RPKM 13.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H5

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (183107091..183151091, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (183326236..183369565, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.
Title: MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.
Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms
Title: Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.
revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family
Title: Characterization and expression pattern of the novel MIA homolog TANGO.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mia3 (e-PCR), detects polymorphism
- UniSTS:546865

AU022327 (e-PCR)
- UniSTS:178536

RH126807 (e-PCR)
- UniSTS:207263

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
involved_in COPII-coated vesicle cargo loading	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lymphocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transport and Golgi organization protein 1 homolog

Names: melanoma inhibitory activity 3; melanoma inhibitory activity protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177389.4 → NP_796363.3 transport and Golgi organization protein 1 homolog precursor

Status: VALIDATED

Source sequence(s)

AEKQ02108037, AEKQ02108038, CAAA01083531

UniProtKB/Swiss-Prot

A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9

UniProtKB/TrEMBL

A0A0R4J2D3

Related

ENSMUSP00000141268.4, ENSMUST00000194543.4

Conserved Domains (4) summary

PHA03247
Location:1014 → 1144

PHA03247; large tegument protein UL36; Provisional

PRK14949
Location:716 → 1119

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

TIGR02168
Location:1241 → 1606

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17036
Location:38 → 109

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

183107091..183151091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165968.1 → XP_036021861.1 transport and Golgi organization protein 1 homolog isoform X3

UniProtKB/Swiss-Prot

A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9

Conserved Domains (4) summary

PHA03247
Location:1014 → 1144

PHA03247; large tegument protein UL36; Provisional

PRK14949
Location:716 → 1119

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

TIGR02168
Location:1241 → 1606

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17036
Location:38 → 109

SH3; Src Homology 3 domain superfamily
XM_036165967.1 → XP_036021860.1 transport and Golgi organization protein 1 homolog isoform X2

UniProtKB/Swiss-Prot

A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9

Conserved Domains (4) summary

PHA03247
Location:1014 → 1144

PHA03247; large tegument protein UL36; Provisional

PRK14949
Location:716 → 1119

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

TIGR02168
Location:1241 → 1606

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17036
Location:38 → 109

SH3; Src Homology 3 domain superfamily
XM_036165966.1 → XP_036021859.1 transport and Golgi organization protein 1 homolog isoform X1

UniProtKB/Swiss-Prot

A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9

Conserved Domains (4) summary

PHA03247
Location:1671 → 1954

PHA03247; large tegument protein UL36; Provisional

PRK14949
Location:716 → 1119

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

TIGR04523
Location:1239 → 1625

Mplasa_alph_rch; helix-rich Mycoplasma protein

cl17036
Location:38 → 109

SH3; Src Homology 3 domain superfamily
XM_036165972.1 → XP_036021865.1 transport and Golgi organization protein 1 homolog isoform X4

Conserved Domains (3) summary

PHA03247
Location:514 → 805

PHA03247; large tegument protein UL36; Provisional

TIGR02168
Location:92 → 457

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam06409
Location:43 → 82

NPIP; Nuclear pore complex interacting protein (NPIP)
XM_036165973.1 → XP_036021866.1 transport and Golgi organization protein 1 homolog isoform X5

Conserved Domains (3) summary

PHA03247
Location:522 → 781

PHA03247; large tegument protein UL36; Provisional

TIGR02168
Location:92 → 457

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam06409
Location:43 → 82

NPIP; Nuclear pore complex interacting protein (NPIP)