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    Nfe2l3 nuclear factor, erythroid derived 2, like 3 [ Mus musculus (house mouse) ]

    Gene ID: 18025, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nfe2l3provided by MGI
    Official Full Name
    nuclear factor, erythroid derived 2, like 3provided by MGI
    Primary source
    MGI:MGI:1339958
    See related
    Ensembl:ENSMUSG00000029832 AllianceGenome:MGI:1339958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrf3
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; forelimb bud; gonad; and ureter. Orthologous to human NFE2L3 (NFE2 like bZIP transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 16.5), CNS E18 (RPKM 5.1) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Nfe2l3 in Genome Data Viewer
    Location:
    6 B3; 6 24.84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51409649..51435752)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51432669..51458772)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6432 Neighboring gene predicted gene, 32479 Neighboring gene STARR-positive B cell enhancer mm9_chr6:51312578-51312879 Neighboring gene STARR-positive B cell enhancer mm9_chr6:51333989-51334289 Neighboring gene STARR-seq mESC enhancer starr_15870 Neighboring gene predicted gene 6559 Neighboring gene STARR-seq mESC enhancer starr_15871 Neighboring gene STARR-seq mESC enhancer starr_15873 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene chromobox 3 Neighboring gene STARR-seq mESC enhancer starr_15875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:51459345-51459528 Neighboring gene STARR-seq mESC enhancer starr_15881 Neighboring gene sorting nexin 10 Neighboring gene predicted gene, 52883

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General protein information

    Preferred Names
    nuclear factor erythroid 2-related factor 3
    Names
    NF-E2-related factor 3
    NFE2-related factor 3
    nuclear factor erythroid 2-like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010903.2NP_035033.1  nuclear factor erythroid 2-related factor 3

      See identical proteins and their annotated locations for NP_035033.1

      Status: VALIDATED

      Source sequence(s)
      AC154011, AK133935, AV237858, CJ045939
      Consensus CDS
      CCDS20134.1
      UniProtKB/Swiss-Prot
      Q9WTM4
      UniProtKB/TrEMBL
      Q3UUW2, Q3UZC1
      Related
      ENSMUSP00000005103.6, ENSMUST00000005103.12
      Conserved Domains (1) summary
      cd14720
      Location:538605
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      51409649..51435752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)