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    Pax7 paired box 7 [ Mus musculus (house mouse) ]

    Gene ID: 18509, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pax7provided by MGI
    Official Full Name
    paired box 7provided by MGI
    Primary source
    MGI:MGI:97491
    See related
    Ensembl:ENSMUSG00000028736 AllianceGenome:MGI:97491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pax-7
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in skeletal muscle satellite cell differentiation. Acts upstream of or within several processes, including nervous system development; positive regulation of myoblast proliferation; and skeletal system development. Is active in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 2.5), CNS E11.5 (RPKM 2.3) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pax7 in Genome Data Viewer
    Location:
    4 D3; 4 70.83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139464357..139560841, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139737059..139833530, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene taste receptor, type 1, member 2 Neighboring gene predicted gene, 42334 Neighboring gene STARR-seq mESC enhancer starr_11839 Neighboring gene STARR-seq mESC enhancer starr_11840 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:139369700-139369901 Neighboring gene predicted gene, 46873 Neighboring gene STARR-seq mESC enhancer starr_11842 Neighboring gene RIKEN cDNA 4933427I22 gene Neighboring gene predicted gene 1667 Neighboring gene STARR-seq mESC enhancer starr_11844 Neighboring gene kelch domain containing 7A Neighboring gene microRNA 2139

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral neural tube patterning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of chromatin organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skeletal muscle satellite cell commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle satellite cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord association neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    paired box protein Pax-7
    Names
    paired box gene 7
    paired box transcription factor PAX7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011039.3NP_035169.1  paired box protein Pax-7

      See identical proteins and their annotated locations for NP_035169.1

      Status: VALIDATED

      Source sequence(s)
      AL831790, AL844480
      Consensus CDS
      CCDS18850.1
      UniProtKB/Swiss-Prot
      P47239, Q9ES16
      Related
      ENSMUSP00000030508.7, ENSMUST00000030508.14
      Conserved Domains (3) summary
      smart00351
      Location:34159
      PAX; Paired Box domain
      pfam00046
      Location:218272
      Homeobox; Homeobox domain
      pfam12360
      Location:345383
      Pax7; Paired box protein 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139464357..139560841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538630.2XP_006538693.1  paired box protein Pax-7 isoform X2

      Conserved Domains (3) summary
      smart00351
      Location:34160
      PAX; Paired Box domain
      pfam00046
      Location:219273
      Homeobox; Homeobox domain
      pfam12360
      Location:346384
      Pax7; Paired box protein 7
    2. XM_006538629.2XP_006538692.1  paired box protein Pax-7 isoform X1

      UniProtKB/TrEMBL
      G3UX36
      Related
      ENSMUSP00000133536.2, ENSMUST00000174681.2
      Conserved Domains (3) summary
      smart00351
      Location:34161
      PAX; Paired Box domain
      pfam00046
      Location:220274
      Homeobox; Homeobox domain
      pfam12360
      Location:347385
      Pax7; Paired box protein 7
    3. XM_006538631.2XP_006538694.1  paired box protein Pax-7 isoform X3

      Conserved Domains (3) summary
      smart00351
      Location:34158
      PAX; Paired Box domain
      pfam00046
      Location:217271
      Homeobox; Homeobox domain
      pfam12360
      Location:344382
      Pax7; Paired box protein 7