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    Ncoa4 nuclear receptor coactivator 4 [ Mus musculus (house mouse) ]

    Gene ID: 27057, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ncoa4provided by MGI
    Official Full Name
    nuclear receptor coactivator 4provided by MGI
    Primary source
    MGI:MGI:1350932
    See related
    Ensembl:ENSMUSG00000056234 AllianceGenome:MGI:1350932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rfg; ARA70
    Summary
    Acts upstream of or within intracellular iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including heart; lung; metanephros; reproductive system; and spleen. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 63.2), liver E14.5 (RPKM 56.4) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ncoa4 in Genome Data Viewer
    Location:
    14 B; 14 19.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31881884..31901210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32159879..32179855)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41127 Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene STARR-seq mESC enhancer starr_36340 Neighboring gene predicted gene, 23946 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene STARR-positive B cell enhancer mm9_chr14:33042212-33042513 Neighboring gene tetratricopeptide repeat domain 35 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    nuclear receptor coactivator 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033988.3NP_001029160.1  nuclear receptor coactivator 4 isoform a

      See identical proteins and their annotated locations for NP_001029160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC154532
      Consensus CDS
      CCDS36863.1
      UniProtKB/Swiss-Prot
      Q3UI10, Q3UJ26, Q3UJ63, Q3UKL9, Q5U4H9, Q9WV42
      UniProtKB/TrEMBL
      Q3UM78
      Related
      ENSMUSP00000126071.2, ENSMUST00000163336.8
      Conserved Domains (1) summary
      pfam12489
      Location:231326
      ARA70; Nuclear coactivator
    2. NM_001284319.2NP_001271248.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
      Conserved Domains (1) summary
      pfam12489
      Location:136231
      ARA70; Nuclear coactivator
    3. NM_001402998.1NP_001389927.1  nuclear receptor coactivator 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    4. NM_001402999.1NP_001389928.1  nuclear receptor coactivator 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    5. NM_001403000.1NP_001389929.1  nuclear receptor coactivator 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    6. NM_001403001.1NP_001389930.1  nuclear receptor coactivator 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    7. NM_001403002.1NP_001389931.1  nuclear receptor coactivator 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    8. NM_001403003.1NP_001389932.1  nuclear receptor coactivator 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/Swiss-Prot
      Q3UI10, Q3UJ26, Q3UJ63, Q3UKL9, Q5U4H9, Q9WV42
      UniProtKB/TrEMBL
      Q3UM78
    9. NM_001403004.1NP_001389933.1  nuclear receptor coactivator 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    10. NM_001403005.1NP_001389934.1  nuclear receptor coactivator 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    11. NM_001403006.1NP_001389935.1  nuclear receptor coactivator 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q3UM78
    12. NM_001403007.1NP_001389936.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
    13. NM_001403008.1NP_001389937.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
    14. NM_001403009.1NP_001389938.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
    15. NM_001403010.1NP_001389939.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
    16. NM_001403011.1NP_001389940.1  nuclear receptor coactivator 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
    17. NM_019744.5NP_062718.2  nuclear receptor coactivator 4 isoform a

      See identical proteins and their annotated locations for NP_062718.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC154532
      Consensus CDS
      CCDS36863.1
      UniProtKB/Swiss-Prot
      Q3UI10, Q3UJ26, Q3UJ63, Q3UKL9, Q5U4H9, Q9WV42
      UniProtKB/TrEMBL
      Q3UM78
      Related
      ENSMUSP00000107625.4, ENSMUST00000111994.10
      Conserved Domains (1) summary
      pfam12489
      Location:231326
      ARA70; Nuclear coactivator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31881884..31901210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)