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    Nes nestin [ Mus musculus (house mouse) ]

    Gene ID: 18008, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nesprovided by MGI
    Official Full Name
    nestinprovided by MGI
    Primary source
    MGI:MGI:101784
    See related
    Ensembl:ENSMUSG00000004891 AllianceGenome:MGI:101784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RC2; Marc2; ESTM46; Ifaprc2
    Summary
    Predicted to enable CCR5 chemokine receptor binding activity and intermediate filament binding activity. Acts upstream of or within cell projection morphogenesis; negative regulation of neuron apoptotic process; and nervous system development. Located in cytoplasm and intermediate filament. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; foregut-midgut junction; and metanephros. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 68.0), CNS E14 (RPKM 14.9) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nes in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87878400..87887758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87971093..87980451)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9216 Neighboring gene predicted gene, 32518 Neighboring gene predicted gene 3745 Neighboring gene STARR-seq mESC enhancer starr_08169 Neighboring gene brevican Neighboring gene hyaluronan and proteoglycan link protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR5 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR5 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables intermediate filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cell projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic camera-type eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intermediate filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of intermediate filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intermediate filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nestin
    Names
    intermediate filament protein
    intermediate filament-associated protein RC2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016701.3NP_057910.3  nestin

      See identical proteins and their annotated locations for NP_057910.3

      Status: VALIDATED

      Source sequence(s)
      BC062893
      Consensus CDS
      CCDS17461.1
      UniProtKB/Swiss-Prot
      A1E2I2, Q6P5H2, Q80X00, Q8BPH7, Q9CV43, Q9R0C4
      Related
      ENSMUSP00000088493.6, ENSMUST00000090973.12
      Conserved Domains (1) summary
      pfam00038
      Location:7313
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87878400..87887758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162920.1XP_036018813.1  nestin isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:281795
      PTZ00121; MAEBL; Provisional
      COG5271
      Location:6061051
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]