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    Zdhhc17 zinc finger, DHHC domain containing 17 [ Mus musculus (house mouse) ]

    Gene ID: 320150, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zdhhc17provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 17provided by MGI
    Primary source
    MGI:MGI:2445110
    See related
    Ensembl:ENSMUSG00000035798 AllianceGenome:MGI:2445110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hip14; DHHC-17; A230053P19Rik; D130071N24Rik
    Summary
    Enables palmitoyltransferase activity and signaling receptor binding activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of modification of synapse structure, modulating synaptic transmission; and regulation of signal transduction. Located in Golgi apparatus. Is active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynaptic Golgi apparatus. Is expressed in several structures, including early conceptus; heart; and oocyte. Used to study Huntington's disease. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 24.0), CNS E18 (RPKM 21.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zdhhc17 in Genome Data Viewer
    Location:
    10 D1; 10 57.86 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (110777640..110848587, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (110941779..111010066, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22236 Neighboring gene cysteine and glycine-rich protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E9351 Neighboring gene predicted gene, 51781 Neighboring gene predicted gene, 29916

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0946

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perforant pathway to dendrate granule cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perforant pathway to dendrate granule cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC17
    Names
    DHHC domain-containing cysteine-rich protein 17
    acyltransferase ZDHHC17
    acyltransferase ZDHHC7
    huntingtin interacting protein 14
    zinc finger DHHC domain-containing protein 17
    NP_001346551.1
    NP_001346553.1
    NP_766142.2
    XP_030100985.1
    XP_036011712.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359622.1NP_001346551.1  palmitoyltransferase ZDHHC17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a shorter 5' UTR than variant 1, and initiates translation at a downstream start codon, compared to variant 1. This variant intiates transcription from a major transcription start site, as determined by CAGE data. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK038670, AK046891, AW911453, BE955669, BQ560505
      UniProtKB/TrEMBL
      Q0VFY6
      Conserved Domains (3) summary
      cd00204
      Location:77192
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:146177
      ANK; ANK repeat [structural motif]
      pfam01529
      Location:428558
      zf-DHHC; DHHC palmitoyltransferase
    2. NM_001359624.1NP_001346553.1  palmitoyltransferase ZDHHC17 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site, resulting in translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK039575, AW911453, BC027101, BE955669
      Conserved Domains (1) summary
      pfam01529
      Location:166296
      DHHC; DHHC palmitoyltransferase
    3. NM_172554.2NP_766142.2  palmitoyltransferase ZDHHC17 isoform 1

      See identical proteins and their annotated locations for NP_766142.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK039575, AK046891, AW911453, BC027101, BC051527
      Consensus CDS
      CCDS56748.1
      UniProtKB/Swiss-Prot
      Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6
      Related
      ENSMUSP00000043279.8, ENSMUST00000041723.15
      Conserved Domains (4) summary
      PHA03095
      Location:100352
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:156187
      ANK; ANK repeat [structural motif]
      pfam01529
      Location:438568
      DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:161255
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      110777640..110848587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155819.1XP_036011712.1  palmitoyltransferase ZDHHC17 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:186316
      DHHC; DHHC palmitoyltransferase
    2. XM_030245125.2XP_030100985.1  palmitoyltransferase ZDHHC17 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:186316
      DHHC; DHHC palmitoyltransferase