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    Grtp1 GH regulated TBC protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grtp1provided by MGI
    Official Full Name
    GH regulated TBC protein 1provided by MGI
    Primary source
    MGI:MGI:1914040
    See related
    Ensembl:ENSMUSG00000038515 AllianceGenome:MGI:1914040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tbc1d6; 5430401C05Rik
    Summary
    Predicted to enable GTPase activator activity. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 14.5), large intestine adult (RPKM 9.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grtp1 in Genome Data Viewer
    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13226869..13250695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13176869..13200766, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1 Neighboring gene RIKEN cDNA 2810030D12 gene Neighboring gene microRNA 1968 Neighboring gene STARR-seq mESC enhancer starr_20764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213467-13213836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213972-13214173 Neighboring gene ADP-ribosylhydrolase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Grtp1, a novel gene regulated by growth hormone. Lu C, et al. Endocrinology, 2001 Oct. PMID 11564724
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    growth hormone-regulated TBC protein 1
    Names
    TBC1 domain family member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368858.1 → NP_001355787.1  growth hormone-regulated TBC protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK007905, AK017251, AK149322
      Consensus CDS
      CCDS90375.1
      UniProtKB/Swiss-Prot
      Q8BUR0, Q8VI03, Q9D3N8, Q9D3Q5, Q9D8L8
      UniProtKB/TrEMBL
      A0A1B0GSA2
      Related
      ENSMUSP00000130324.4, ENSMUST00000165605.4
      Conserved Domains (1) summary
      smart00164
      Location:71 → 301
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_025768.2 → NP_080044.2  growth hormone-regulated TBC protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080044.2

      Status: VALIDATED

      Source sequence(s)
      AK007905, AK149322
      Consensus CDS
      CCDS22107.1
      UniProtKB/TrEMBL
      A0A1B0GSA2
      Related
      ENSMUSP00000148042.2, ENSMUST00000210317.2
      Conserved Domains (1) summary
      smart00164
      Location:71 → 284
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13226869..13250695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508853.4 → XP_006508916.1  growth hormone-regulated TBC protein 1 isoform X3

      Conserved Domains (1) summary
      pfam00566
      Location:1 → 122
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. XM_006508850.5 → XP_006508913.1  growth hormone-regulated TBC protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSA2
      Conserved Domains (1) summary
      smart00164
      Location:71 → 284
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. XM_006508851.5 → XP_006508914.1  growth hormone-regulated TBC protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006508914.1

      UniProtKB/TrEMBL
      A0A1B0GSA2
      Related
      ENSMUSP00000147337.2, ENSMUST00000211128.2
      Conserved Domains (1) summary
      smart00164
      Location:71 → 284
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RNA

    1. XR_378665.4 RNA Sequence

    2. XR_003947326.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3N8.1 GenPept UniProtKB/Swiss-Prot:Q9D3N8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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