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    Cdca2 cell division cycle associated 2 [ Mus musculus (house mouse) ]

    Gene ID: 108912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdca2provided by MGI
    Official Full Name
    cell division cycle associated 2provided by MGI
    Primary source
    MGI:MGI:1919787
    See related
    Ensembl:ENSMUSG00000048922 AllianceGenome:MGI:1919787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610311M19Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Acts upstream of or within chromosome segregation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including brain; liver; lung; metanephros; and retina nuclear layer. Orthologous to human CDCA2 (cell division cycle associated 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 12.3), CNS E11.5 (RPKM 7.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdca2 in Genome Data Viewer
    Location:
    14 D1; 14 34.66 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67910629..67953290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (67673180..67715841, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37012 Neighboring gene predicted gene, 38409 Neighboring gene predicted gene, 24981 Neighboring gene STARR-seq mESC enhancer starr_37015 Neighboring gene potassium channel tetramerisation domain containing 9 Neighboring gene gonadotropin releasing hormone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. Wurzenberger C, et al. J Cell Biol, 2012 Jul 23. PMID 22801782, Free PMC Article
    2. GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Kang HS, et al. Cell Mol Life Sci, 2024 Jan 28. PMID 38281222, Free PMC Article
    3. Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Xie L, et al. Dev Cell, 2012 Aug 14. PMID 22898775, Free PMC Article
    4. Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Naiman N, et al. Dev Cell, 2017 May 22. PMID 28535371, Free PMC Article
    5. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110162.1 → NP_001103632.1  cell division cycle-associated protein 2

      See identical proteins and their annotated locations for NP_001103632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript.
      Source sequence(s)
      AK160223, AK166952, BC067009, CD354922
      Consensus CDS
      CCDS36962.2
      UniProtKB/Swiss-Prot
      Q14B71, Q8BSQ1, Q8CD75
      Related
      ENSMUSP00000127571.2, ENSMUST00000163100.8
      Conserved Domains (1) summary
      pfam15276
      Location:379 → 435
      PP1_bind; Protein phosphatase 1 binding

    2. NM_175384.4 → NP_780593.3  cell division cycle-associated protein 2

      See identical proteins and their annotated locations for NP_780593.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC067009, BC075682
      Consensus CDS
      CCDS36962.2
      UniProtKB/Swiss-Prot
      Q14B71, Q8BSQ1, Q8CD75
      Related
      ENSMUSP00000117847.3, ENSMUST00000150006.9
      Conserved Domains (1) summary
      pfam15276
      Location:379 → 435
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      67910629..67953290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247603.1 → XP_030103463.1  cell division cycle-associated protein 2 isoform X3

      Conserved Domains (1) summary
      pfam15276
      Location:379 → 434
      PP1_bind; Protein phosphatase 1 binding

    2. XM_030247602.2 → XP_030103462.1  cell division cycle-associated protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15276
      Location:380 → 435
      PP1_bind; Protein phosphatase 1 binding

    3. XM_006518420.5 → XP_006518483.1  cell division cycle-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518483.1

      UniProtKB/Swiss-Prot
      Q14B71, Q8BSQ1, Q8CD75
      Conserved Domains (1) summary
      pfam15276
      Location:379 → 435
      PP1_bind; Protein phosphatase 1 binding

    4. XM_030247604.2 → XP_030103464.1  cell division cycle-associated protein 2 isoform X4

      Conserved Domains (1) summary
      pfam15276
      Location:379 → 434
      PP1_bind; Protein phosphatase 1 binding

    5. XM_011244913.4 → XP_011243215.1  cell division cycle-associated protein 2 isoform X3

      Conserved Domains (1) summary
      pfam15276
      Location:379 → 434
      PP1_bind; Protein phosphatase 1 binding

    6. XM_011244912.4 → XP_011243214.1  cell division cycle-associated protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15276
      Location:380 → 435
      PP1_bind; Protein phosphatase 1 binding

    7. XM_030247605.1 → XP_030103465.1  cell division cycle-associated protein 2 isoform X6

      Conserved Domains (1) summary
      pfam15276
      Location:234 → 289
      PP1_bind; Protein phosphatase 1 binding

    8. XM_006518423.2 → XP_006518486.1  cell division cycle-associated protein 2 isoform X5

      Conserved Domains (1) summary
      pfam15276
      Location:234 → 289
      PP1_bind; Protein phosphatase 1 binding

    9. XM_011244915.4 → XP_011243217.1  cell division cycle-associated protein 2 isoform X7

      UniProtKB/TrEMBL
      D3YZE8
      Related
      ENSMUSP00000115633.2, ENSMUST00000132705.8
      Conserved Domains (1) summary
      pfam15276
      Location:380 → 435
      PP1_bind; Protein phosphatase 1 binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14B71.2 GenPept UniProtKB/Swiss-Prot:Q14B71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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