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    Igsf21 immunoglobulin superfamily, member 21 [ Mus musculus (house mouse) ]

    Gene ID: 230868, updated on 9-Dec-2024

    Summary

    Official Symbol
    Igsf21provided by MGI
    Official Full Name
    immunoglobulin superfamily, member 21provided by MGI
    Primary source
    MGI:MGI:2681842
    See related
    Ensembl:ENSMUSG00000040972 AllianceGenome:MGI:2681842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm141
    Summary
    Involved in synapse maturation and trans-synaptic signaling, modulating synaptic transmission. Located in external side of plasma membrane; inhibitory synapse; and presynaptic membrane. Is active in postsynaptic density membrane. Is expressed in several structures, including brain; ganglia; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human IGSF21 (immunoglobin superfamily member 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 14.5), frontal lobe adult (RPKM 13.6) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Igsf21 in Genome Data Viewer
    Location:
    4 D3; 4 71.09 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139754163..139974294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140026852..140246983, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933427I22 gene Neighboring gene predicted gene 1667 Neighboring gene STARR-seq mESC enhancer starr_11844 Neighboring gene STARR-seq mESC enhancer starr_11846 Neighboring gene kelch domain containing 7A Neighboring gene microRNA 2139 Neighboring gene STARR-seq mESC enhancer starr_11847 Neighboring gene predicted gene, 52685 Neighboring gene VISTA enhancer mm1730 Neighboring gene STARR-seq mESC enhancer starr_11853 Neighboring gene STARR-seq mESC enhancer starr_11854 Neighboring gene STARR-seq mESC enhancer starr_11855 Neighboring gene predicted gene 13029 Neighboring gene predicted gene, 33542 Neighboring gene predicted gene, 33895 Neighboring gene predicted gene, 53244 Neighboring gene predicted gene 9867

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

    Markers

    Clone Names

    • MGC67646

    General protein information

    Preferred Names
    immunoglobulin superfamily member 21
    Names
    immunoglobin superfamily, member 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198610.2NP_941012.1  immunoglobulin superfamily member 21 precursor

      See identical proteins and their annotated locations for NP_941012.1

      Status: VALIDATED

      Source sequence(s)
      BB867903, BC055811
      Consensus CDS
      CCDS18851.1
      UniProtKB/Swiss-Prot
      Q7TNR6
      Related
      ENSMUSP00000046558.9, ENSMUST00000039331.9
      Conserved Domains (2) summary
      smart00410
      Location:353430
      IG_like; Immunoglobulin like
      cl11960
      Location:369432
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139754163..139974294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538799.4XP_006538862.1  immunoglobulin superfamily member 21 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:175235
      Ig; Immunoglobulin domain