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    Zfp619 zinc finger protein 619 [ Mus musculus (house mouse) ]

    Gene ID: 70227, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp619provided by MGI
    Official Full Name
    zinc finger protein 619provided by MGI
    Primary source
    MGI:MGI:1917477
    See related
    Ensembl:ENSMUSG00000068959 AllianceGenome:MGI:1917477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3000002G13Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF850 (zinc finger protein 850). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 1.3), CNS E14 (RPKM 1.2) and 24 other tissues See more
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    Genomic context

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    See Zfp619 in Genome Data Viewer
    Location:
    7 B3; 7 25.48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (39165143..39189844)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (39517766..39540415)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 939 Neighboring gene predicted gene, 51478 Neighboring gene predicted gene 28455 Neighboring gene STARR-seq mESC enhancer starr_18699 Neighboring gene STARR-positive B cell enhancer ABC_E9109 Neighboring gene predicted gene, 33989 Neighboring gene STARR-positive B cell enhancer ABC_E6538 Neighboring gene STARR-seq mESC enhancer starr_18702 Neighboring gene STARR-seq mESC enhancer starr_18703 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2H pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC91101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 91

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004139.3 → NP_001004139.2  zinc finger protein 91

      See identical proteins and their annotated locations for NP_001004139.2

      Status: VALIDATED

      Source sequence(s)
      AC113955
      Consensus CDS
      CCDS39918.1
      UniProtKB/TrEMBL
      G3X9T2
      Related
      ENSMUSP00000103650.2, ENSMUST00000108015.4
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:327 → 735
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:668 → 688
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:956 → 981
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      39165143..39189844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153431.1 → XP_036009324.1  zinc finger protein 91 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:380 → 788
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:721 → 741
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 44
      KRAB; KRAB box
      pfam13465
      Location:286 → 310
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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