U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Padi4 peptidyl arginine deiminase, type IV [ Mus musculus (house mouse) ]

    Gene ID: 18602, updated on 9-Dec-2024

    Summary

    Official Symbol
    Padi4provided by MGI
    Official Full Name
    peptidyl arginine deiminase, type IVprovided by MGI
    Primary source
    MGI:MGI:1338898
    See related
    Ensembl:ENSMUSG00000025330 AllianceGenome:MGI:1338898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pad4; Pdi4
    Summary
    Enables protein-arginine deiminase activity. Involved in nucleosome assembly and stem cell population maintenance. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in blastocyst; early embryo; and oocyte. Orthologous to human PADI4 (peptidyl arginine deiminase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 6.8), bladder adult (RPKM 5.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Padi4 in Genome Data Viewer
    Location:
    4 D3; 4 72.34 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140472819..140501514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140745508..140774239, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11875 Neighboring gene regulator of chromosome condensation 2 Neighboring gene STARR-positive B cell enhancer ABC_E8005 Neighboring gene peptidyl arginine deiminase, type VI Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140306464-140306665 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140338844-140339025 Neighboring gene predicted gene, 52482 Neighboring gene peptidyl arginine deiminase, type III Neighboring gene predicted gene 13032 Neighboring gene peptidyl arginine deiminase, type I

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H1R54 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AR3 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R17 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R17 arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3R2 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R2 arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3R26 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R26 arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3R8 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R8 arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4R3 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone arginine deiminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine deiminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine deiminase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-arginine deiminase type-4
    Names
    PAD type IV
    peptidylarginine deiminase IV
    protein-arginine deiminase type IV
    NP_035191.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011061.2NP_035191.2  protein-arginine deiminase type-4

      See identical proteins and their annotated locations for NP_035191.2

      Status: VALIDATED

      Source sequence(s)
      AB013850, AI645912, AK137625, BY544067
      Consensus CDS
      CCDS18854.1
      UniProtKB/Swiss-Prot
      A2AMU3, Q75WC7, Q9Z183
      Related
      ENSMUSP00000026381.7, ENSMUST00000026381.7
      Conserved Domains (3) summary
      pfam03068
      Location:286663
      PAD; Protein-arginine deiminase (PAD)
      pfam08526
      Location:1111
      PAD_N; Protein-arginine deiminase (PAD) N-terminal domain
      pfam08527
      Location:113272
      PAD_M; Protein-arginine deiminase (PAD) middle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140472819..140501514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)