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    Zbtb33 zinc finger and BTB domain containing 33 [ Mus musculus (house mouse) ]

    Gene ID: 56805, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb33provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 33provided by MGI
    Primary source
    MGI:MGI:1927290
    See related
    Ensembl:ENSMUSG00000048047 AllianceGenome:MGI:1927290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kaiso; Znf-kaiso; E130014G12Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to act upstream of or within DNA-templated transcription. Located in nucleus. Is expressed in several structures, including bladder; central nervous system; early conceptus; eye; and gonad. Orthologous to human ZBTB33 (zinc finger and BTB domain containing 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.7), CNS E18 (RPKM 8.6) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zbtb33 in Genome Data Viewer
    Location:
    X A3.3; X 22.45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37278670..37285923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38189793..38197046)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39506 Neighboring gene reproductive homeobox 13 Neighboring gene STARR-seq mESC enhancer starr_47013 Neighboring gene zinc finger protein 36, C3H type-like 1, pseudogene Neighboring gene STARR-seq mESC enhancer starr_47014 Neighboring gene transmembrane protein 255A Neighboring gene STARR-seq mESC enhancer starr_47015 Neighboring gene microRNA 3110 Neighboring gene predicted gene, 39507

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyl-CpG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcriptional regulator Kaiso
    Names
    zinc finger and BTB domain-containing protein 33
    zinc finger transcription factor Kaiso

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079513.1NP_001072981.1  transcriptional regulator Kaiso

      See identical proteins and their annotated locations for NP_001072981.1

      Status: VALIDATED

      Source sequence(s)
      AK087417, AL512346, BY200826
      Consensus CDS
      CCDS30088.1
      UniProtKB/Swiss-Prot
      Q8BN78, Q8C226, Q9WTZ7
      UniProtKB/TrEMBL
      A2A3Z2, A2A3Z3
      Related
      ENSMUSP00000110795.3, ENSMUST00000115142.3
      Conserved Domains (4) summary
      smart00225
      Location:33116
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:494514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22116
      BTB; BTB/POZ domain
      pfam13465
      Location:506529
      zf-H2C2_2; Zinc-finger double domain
    2. NM_020256.2NP_064652.2  transcriptional regulator Kaiso

      See identical proteins and their annotated locations for NP_064652.2

      Status: VALIDATED

      Source sequence(s)
      AK087417, AK089423, AL512346, BY200826
      Consensus CDS
      CCDS30088.1
      UniProtKB/Swiss-Prot
      Q8BN78, Q8C226, Q9WTZ7
      UniProtKB/TrEMBL
      A2A3Z2, A2A3Z3
      Related
      ENSMUSP00000049983.3, ENSMUST00000049740.3
      Conserved Domains (4) summary
      smart00225
      Location:33116
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:494514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22116
      BTB; BTB/POZ domain
      pfam13465
      Location:506529
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      37278670..37285923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)