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    Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [ Mus musculus (house mouse) ]

    Gene ID: 67680, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sdhbprovided by MGI
    Official Full Name
    succinate dehydrogenase complex, subunit B, iron sulfur (Ip)provided by MGI
    Primary source
    MGI:MGI:1914930
    See related
    Ensembl:ENSMUSG00000009863 AllianceGenome:MGI:1914930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0710008N11Rik
    Summary
    Predicted to enable iron-sulfur cluster binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Predicted to be involved in aerobic respiration; respiratory electron transport chain; and succinate metabolic process. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 390.1), kidney adult (RPKM 243.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sdhb in Genome Data Viewer
    Location:
    4 D3; 4 73.24 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140688582..140706509)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140961271..140979198)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase, type II Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140486954-140487137 Neighboring gene predicted gene, 34375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140500844-140501166 Neighboring gene STARR-positive B cell enhancer mm9_chr4:140501133-140501433 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140508500-140508683 Neighboring gene predicted gene 13031 Neighboring gene STARR-seq mESC enhancer starr_11883 Neighboring gene STARR-positive B cell enhancer ABC_E10271 Neighboring gene STARR-positive B cell enhancer ABC_E6248 Neighboring gene ATPase type 13A2 Neighboring gene microfibrillar-associated protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3 iron, 4 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 4 iron, 4 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables succinate dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables succinate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquinone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial electron transport, succinate to ubiquinone NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in succinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex II (succinate dehydrogenase) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of respiratory chain complex II (succinate dehydrogenase) ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Names
    ip
    iron-sulfur subunit of complex II
    malate dehydrogenase [quinone] iron-sulfur subunit
    succinate dehydrogenase complex subunit B
    NP_001342444.1
    NP_075863.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355515.1NP_001342444.1  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is two aa shorter than isoform 1.
      Source sequence(s)
      AI835380, BC051934, BY111239
      UniProtKB/TrEMBL
      Q3TE45
      Conserved Domains (1) summary
      PLN00129
      Location:1271
      PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit
    2. NM_023374.4NP_075863.2  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_075863.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI835380, BC051934
      Consensus CDS
      CCDS18858.1
      UniProtKB/Swiss-Prot
      Q3TF82, Q9CQA3, Q9DC91
      UniProtKB/TrEMBL
      Q3TE45
      Related
      ENSMUSP00000010007.9, ENSMUST00000010007.9
      Conserved Domains (3) summary
      PRK05950
      Location:43274
      sdhB; succinate dehydrogenase iron-sulfur subunit; Reviewed
      pfam13085
      Location:43149
      Fer2_3; 2Fe-2S iron-sulfur cluster binding domain
      pfam13534
      Location:187260
      Fer4_17; 4Fe-4S dicluster domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140688582..140706509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)