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    Mettl4 methyltransferase 4, N6-adenosine [ Mus musculus (house mouse) ]

    Gene ID: 76781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl4provided by MGI
    Official Full Name
    methyltransferase 4, N6-adenosineprovided by MGI
    Primary source
    MGI:MGI:1924031
    See related
    Ensembl:ENSMUSG00000055660 AllianceGenome:MGI:1924031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HsT661; 2410198H06Rik; A730091E08Rik
    Summary
    Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in negative regulation of gene expression, epigenetic. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.7), CNS E11.5 (RPKM 3.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl4 in Genome Data Viewer
    Location:
    17 E5; 17 61.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (95030018..95057579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (94722590..94750214, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9416 Neighboring gene STARR-seq mESC enhancer starr_43640 Neighboring gene predicted gene, 41655 Neighboring gene STARR-seq mESC enhancer starr_43642 Neighboring gene STARR-seq mESC enhancer starr_43643 Neighboring gene STARR-seq mESC enhancer starr_43644 Neighboring gene NDC80 homolog, kinetochore complex component pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:95148921-95149221 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95149244-95149545 Neighboring gene STARR-positive B cell enhancer ABC_E8926 Neighboring gene predicted gene 1976 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 7 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95233967-95234268 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95235804-95236104 Neighboring gene signal recognition particle 19 kDa protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase. Zhang Z, et al. Sci Rep, 2020 May 19. PMID 32427889, Free PMC Article
    2. METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells. Sang A, et al. Free Radic Biol Med, 2024 Mar. PMID 38224757
    3. An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing. Kweon SM, et al. Mol Cell, 2019 Jun 20. PMID 30982744, Free PMC Article
    4. m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells. Wang Y, et al. Diabetes, 2020 Aug. PMID 32404350
    5. The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine. Xiao Z, et al. Front Cell Dev Biol, 2022. PMID 35874829, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells.
      Title: METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells.
    2. Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase.
      Title: Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase.
    3. It has been shown that 6methyladenine (6 mA) deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA accumulation in genic elements corresponds with transcriptional silencing.
      Title: An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables site-specific DNA-methyltransferase (adenine-specific) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables site-specific DNA-methyltransferase (adenine-specific) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA (adenine-N6)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA (adenine-N6)-methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N(6)-adenine-specific methyltransferase METTL4
    Names
    N(6)-adenine-specific DNA methyltransferase METTL4
    methyltransferase like 4
    methyltransferase-like protein 4
    snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4
    NP_001344064.1
    NP_001344065.1
    NP_001344066.1
    NP_001344067.1
    NP_795891.2
    XP_011245012.1
    XP_036016723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357135.2 → NP_001344064.1  N(6)-adenine-specific methyltransferase METTL4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165075
      Consensus CDS
      CCDS29030.1
      UniProtKB/Swiss-Prot
      Q3U034
      Conserved Domains (1) summary
      cl01947
      Location:280 → 454
      MT-A70

    2. NM_001357136.2 → NP_001344065.1  N(6)-adenine-specific methyltransferase METTL4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165075
      Consensus CDS
      CCDS29030.1
      UniProtKB/Swiss-Prot
      Q3U034
      Conserved Domains (1) summary
      cl01947
      Location:280 → 454
      MT-A70

    3. NM_001357137.2 → NP_001344066.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165075
      Consensus CDS
      CCDS89172.1
      UniProtKB/TrEMBL
      A4FTY8
      Related
      ENSMUSP00000127142.3, ENSMUST00000171284.3
      Conserved Domains (1) summary
      cl01947
      Location:259 → 433
      MT-A70

    4. NM_001357138.2 → NP_001344067.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165075
      Consensus CDS
      CCDS89172.1
      UniProtKB/TrEMBL
      A4FTY8
      Conserved Domains (1) summary
      cl01947
      Location:259 → 433
      MT-A70

    5. NM_176917.6 → NP_795891.2  N(6)-adenine-specific methyltransferase METTL4 isoform 1

      See identical proteins and their annotated locations for NP_795891.2

      Status: VALIDATED

      Source sequence(s)
      AC165075
      Consensus CDS
      CCDS29030.1
      UniProtKB/Swiss-Prot
      Q3U034
      Related
      ENSMUSP00000157180.2, ENSMUST00000234990.2
      Conserved Domains (1) summary
      cl01947
      Location:280 → 454
      MT-A70

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      95030018..95057579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160830.1 → XP_036016723.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

      Conserved Domains (1) summary
      cl01947
      Location:259 → 401
      MT-A70

    2. XM_011246710.3 → XP_011245012.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:280 → 422
      MT-A70

    RNA

    1. XR_001782127.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U034.1 GenPept UniProtKB/Swiss-Prot:Q3U034

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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