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    Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 330721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek5provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 5provided by MGI
    Primary source
    MGI:MGI:2142824
    See related
    Ensembl:ENSMUSG00000037738 AllianceGenome:MGI:2142824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6530411J22
    Summary
    Enables protein kinase activity. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity and positive regulation of striated muscle cell differentiation. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human NEK5 (NIMA related kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Nek5 in Genome Data Viewer
    Location:
    8 A2; 8 10.95 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22563631..22615443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22073615..22125418, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, copper transporting, beta polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E2858 Neighboring gene STARR-seq mESC enhancer starr_20897 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene STARR-seq mESC enhancer starr_20898 Neighboring gene predicted gene, 57529 Neighboring gene STARR-seq mESC enhancer starr_20899 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3 Neighboring gene STARR-seq mESC enhancer starr_20900 Neighboring gene STARR-seq mESC enhancer starr_20901 Neighboring gene cytoskeleton associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development. Li YY, et al. Mol Reprod Dev, 2019 Sep. PMID 31304658
    2. Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. Shimizu K, et al. FEBS Lett, 2013 Jul 11. PMID 23727203
    3. Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Forrest AR, et al. Genome Res, 2003 Jun. PMID 12819135, Free PMC Article
    4. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nek5 promotes myogenic differentiation through up-regulation of caspase-3 activity.
      Title: Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek5
    Names
    never in mitosis A-related kinase 5
    nimA-related protein kinase 5
    NP_001334247.1
    NP_808566.2
    XP_006509217.1
    XP_006509218.1
    XP_006509222.1
    XP_011240445.1
    XP_011240446.1
    XP_011240447.1
    XP_011240448.1
    XP_011240449.1
    XP_011240451.1
    XP_017168352.1
    XP_030099482.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347318.2 → NP_001334247.1  serine/threonine-protein kinase Nek5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
      Source sequence(s)
      AK032672, AK054168, BC053516
      Consensus CDS
      CCDS85511.1
      UniProtKB/Swiss-Prot
      Q7TSC3, Q8C6N6, Q8CCJ0
      Related
      ENSMUSP00000148211.2, ENSMUST00000209656.2

    2. NM_177898.5 → NP_808566.2  serine/threonine-protein kinase Nek5 isoform 1

      See identical proteins and their annotated locations for NP_808566.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK032672, AK054168
      Consensus CDS
      CCDS52518.1
      UniProtKB/Swiss-Prot
      Q7TSC3
      Related
      ENSMUSP00000126705.2, ENSMUST00000169834.2
      Conserved Domains (2) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
      smart00220
      Location:4 → 255
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22563631..22615443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242145.3 → XP_011240447.1  serine/threonine-protein kinase Nek5 isoform X6

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    2. XM_006509155.5 → XP_006509218.1  serine/threonine-protein kinase Nek5 isoform X3

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    3. XM_030243622.2 → XP_030099482.1  serine/threonine-protein kinase Nek5 isoform X4

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    4. XM_011242144.3 → XP_011240446.1  serine/threonine-protein kinase Nek5 isoform X5

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    5. XM_011242146.4 → XP_011240448.1  serine/threonine-protein kinase Nek5 isoform X9

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    6. XM_011242149.4 → XP_011240451.1  serine/threonine-protein kinase Nek5 isoform X11

    7. XM_006509154.4 → XP_006509217.1  serine/threonine-protein kinase Nek5 isoform X1

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    8. XM_011242143.3 → XP_011240445.1  serine/threonine-protein kinase Nek5 isoform X2

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    9. XM_017312863.3 → XP_017168352.1  serine/threonine-protein kinase Nek5 isoform X7

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    10. XM_006509159.5 → XP_006509222.1  serine/threonine-protein kinase Nek5 isoform X8

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    11. XM_011242147.3 → XP_011240449.1  serine/threonine-protein kinase Nek5 isoform X10

      Conserved Domains (1) summary
      cd08225
      Location:3 → 255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    RNA

    1. XR_003947310.2 RNA Sequence

    2. XR_004934846.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSC3.1 GenPept UniProtKB/Swiss-Prot:Q7TSC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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