Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ywhabprovided by MGI
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideprovided by MGI
Primary source: MGI:MGI:1891917
See related: Ensembl:ENSMUSG00000018326 AllianceGenome:MGI:1891917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 14-3-3b; 1300003C17Rik
Summary: Enables protein domain specific binding activity. Acts upstream of or within protein targeting. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; nervous system; palatal shelf; retina layer; and thymus. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 73.1), CNS E18 (RPKM 72.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 84.59 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (163837082..163860508)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (163995197..164018588)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

14-3-3beta isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
Title: 14-3-3β isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
Title: The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
14-3-3 proteins beta and gamma can potentially be used as a cerebrospinal fluid marker of neuronal damage in parasitic eosinophilic meningitis caused by A
Title: Increased 14-3-3β and γ protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice.
Data indicate 14-3-3 beta protein as an interacting partner of type 1 cannabinoid receptor (CB1R).
Title: Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3β.
SelW enhances myoblast differentiation by inhibiting TAZ binding to 14-3-3.
Title: Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein.
the novel protein interaction mode in the 14-3-3beta.ChREBP alpha2 complex.
Title: Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein.
Studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins.
Title: Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes.
Akt1 is necessary for the growth factor stimulated activation of 14-3-3beta-Rac1-p21 activated kinase (Pak) pathway in endothelial cells and fibroblasts.
Title: 14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly.
aldosterone-induced 14-3-3 isoforms, beta and epsilon, interact with phospho-Nedd4-2 as an obligatory heterodimer, blocking its interaction with ENaC and thereby increasing apical ENaC density and sodium transport.
Title: An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.
FBI1 and 14-3-3beta were presented on the MKP-1 promoter. These results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis.
Title: A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S528E (e-PCR)
- UniSTS:150763

STS-N23075 (e-PCR)
- UniSTS:6129

Ywhab (e-PCR), detects polymorphism
- UniSTS:527609

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables phosphoserine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphoserine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic sequestering of protein	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic sequestering of protein	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 14-3-3 protein beta/alpha

Names: 14-3-3 protein beta; KCIP-1; protein kinase C inhibitor protein 1; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418430.1 → NP_001405359.1 14-3-3 protein beta/alpha

Status: VALIDATED

Source sequence(s)

AL591542

UniProtKB/Swiss-Prot

O70455, Q3TY33, Q3UAN6, Q9CQV8

UniProtKB/TrEMBL

A2A5N2
NM_001418433.1 → NP_001405362.1 14-3-3 protein beta/alpha

Status: VALIDATED

Source sequence(s)

AL591542

UniProtKB/Swiss-Prot

O70455, Q3TY33, Q3UAN6, Q9CQV8

UniProtKB/TrEMBL

A2A5N2
NM_001418434.1 → NP_001405363.1 14-3-3 protein beta/alpha

Status: VALIDATED

Source sequence(s)

AL591542

UniProtKB/Swiss-Prot

O70455, Q3TY33, Q3UAN6, Q9CQV8

UniProtKB/TrEMBL

A2A5N2
NM_018753.7 → NP_061223.2 14-3-3 protein beta/alpha

See identical proteins and their annotated locations for NP_061223.2

Status: VALIDATED

Source sequence(s)

AL591542

Consensus CDS

CCDS17019.1

UniProtKB/Swiss-Prot

O70455, Q3TY33, Q3UAN6, Q9CQV8

UniProtKB/TrEMBL

A2A5N2

Related

ENSMUSP00000018470.4, ENSMUST00000018470.10

Conserved Domains (1) summary

cl02098
Location:4 → 232

14-3-3; 14-3-3 domain