Tti1 TELO2 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tti1provided by MGI
Official Full Name: TELO2 interacting protein 1provided by MGI
Primary source: MGI:MGI:1922675
See related: Ensembl:ENSMUSG00000027650 AllianceGenome:MGI:1922675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610036D13Rik
Summary: Predicted to be involved in positive regulation of DNA damage checkpoint and regulation of TOR signaling. Predicted to be part of TORC1 complex; TORC2 complex; and TTT Hsp90 cochaperone complex. Predicted to be active in cytoplasm. Orthologous to human TTI1 (TELO2 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 9.0), CNS E11.5 (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 78.68 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (157823723..157870382, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (157981803..158028475, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program.
Title: Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234570

AI449463 (e-PCR)
- UniSTS:159063

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in positive regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info
part_of TORC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TTT Hsp90 cochaperone complex	IEA Inferred from Electronic Annotation more info
part_of TTT Hsp90 cochaperone complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TELO2-interacting protein 1 homolog

Names: TEL2-interacting protein 1 homolog; Tel2 interacting protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.