Kcmf1 potassium channel modulatory factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcmf1provided by MGI
Official Full Name: potassium channel modulatory factor 1provided by MGI
Primary source: MGI:MGI:1921537
See related: Ensembl:ENSMUSG00000055239 AllianceGenome:MGI:1921537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pmcf; Debt91; 1700094M07Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of HRI-mediated signaling; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 46.7), ovary adult (RPKM 17.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (72818097..72876962, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (72841114..72899979, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCMF1 mediates pro-oncogenic functions in vitro and in vivo and downregulation of KCMF1 results in the inhibition of pancreatic cancer formation in mice
Title: The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice.
Data suggest that Debt91 is an immediate early gene up-regulated during growth factor-induced branching tubulogenesis.
Title: Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB041536 (e-PCR)
- UniSTS:185669

Kcmf1 (e-PCR), detects polymorphism
- UniSTS:531453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of HRI-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase KCMF1

Names: RING-type E3 ubiquitin transferase KCMF1; clone DEBT-91; debt-91; differentially expressed in branching tubulogenesis 91; potassium channel modulatory factor DEBT-91

NP_001334160.1

EC 2.3.2.27

NP_062689.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347231.1 → NP_001334160.1 E3 ubiquitin-protein ligase KCMF1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC153613

Consensus CDS

CCDS85066.1

UniProtKB/TrEMBL

A0A0N4SV15

Related

ENSMUSP00000144910.2, ENSMUST00000204598.3

Conserved Domains (1) summary

pfam05605
Location:26 → 85

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
NM_019715.2 → NP_062689.2 E3 ubiquitin-protein ligase KCMF1 isoform 1

See identical proteins and their annotated locations for NP_062689.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC153613, AK142436, CX734813

Consensus CDS

CCDS39518.1

UniProtKB/Swiss-Prot

Q80UY2, Q9WUM2

Related

ENSMUSP00000064410.9, ENSMUST00000068697.11

Conserved Domains (3) summary

cd02338
Location:7 → 55

ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...

pfam05605
Location:76 → 137

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam14571
Location:280 → 328

Di19_C; Stress-induced protein Di19, C-terminal