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    CYP703A2 cytochrome P450, family 703, subfamily A, polypeptide 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839470, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP703A2
    Official Full Name
    cytochrome P450, family 703, subfamily A, polypeptide 2
    Primary source
    TAIR:AT1G01280
    Locus tag
    AT1G01280
    See related
    Araport:AT1G01280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; CYP703; cytochrome P450; F6F3.8; F6F3_8; family 703; polypeptide 2; polypeptide 2''; subfamily A
    Summary
    member of CYP703A CYP703A2 is expressed specifically in anthers of land plants, catalyzing the in-chain hydroxylation at the C-7 position of medium-chain saturated fatty acids (lauric acid in-chain hydroxylase) which is involved in pollen development (sporopollenin synthesis).
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    Genomic context

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    See CYP703A2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (112263..113947)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene tRNA-Gln Neighboring gene cofactor of nitrate reductase and xanthine dehydrogenase 3 Neighboring gene Eukaryotic aspartyl protease family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen. Morant M, et al. Plant Cell, 2007 May. PMID 17496121, Free PMC Article
    2. The transcription factors MS188 and AMS form a complex to activate the expression of CYP703A2 for sporopollenin biosynthesis in Arabidopsis thaliana. Xiong SX, et al. Plant J, 2016 Dec. PMID 27460657
    3. Slowing development restores the fertility of thermo-sensitive male-sterile plant lines. Zhu J, et al. Nat Plants, 2020 Apr. PMID 32231254
    4. A large-scale genetic screen in Arabidopsis to identify genes involved in pollen exine production. Dobritsa AA, et al. Plant Physiol, 2011 Oct. PMID 21849515, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate that in-chain hydroxy lauric acids are essential building blocks in sporopollenin synthesis and enable the formation of ester and ether linkages with phenylpropanoid units.
      Title: CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_100010.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within medium-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within medium-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen exine formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sporopollenin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sporopollenin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 703, subfamily A, polypeptide 2
    NP_171635.1
    • ''cytochrome P450, family 703, subfamily A, polypeptide 2'' (CYP703A2); FUNCTIONS IN: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen, oxygen binding; INVOLVED IN: medium-chain fatty acid metabolic process, pollen wall assembly, medium-chain fatty acid biosynthetic process, sporopollenin biosynthetic process, pollen exine formation; LOCATED IN: endomembrane system; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: Cytochrome P450 superfamily protein (TAIR:AT5G07990.1); Has 29652 Blast hits to 29399 proteins in 1569 species: Archae - 44; Bacteria - 2451; Metazoa - 11172; Fungi - 6019; Plants - 9091; Viruses - 3; Other Eukaryotes - 872 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      112263..113947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100010.3 → NP_171635.1  cytochrome P450, family 703, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171635.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNJ4
      UniProtKB/TrEMBL
      A0A178WMS1, A0A5S9S0X8
      Conserved Domains (1) summary
      PLN03112
      Location:1 → 510
      PLN03112; cytochrome P450 family protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LNJ4.1

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