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    Eapp E2F-associated phosphoprotein [ Mus musculus (house mouse) ]

    Gene ID: 66266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eappprovided by MGI
    Official Full Name
    E2F-associated phosphoproteinprovided by MGI
    Primary source
    MGI:MGI:1913516
    See related
    Ensembl:ENSMUSG00000054302 AllianceGenome:MGI:1913516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810011O16Rik
    Summary
    Predicted to act upstream of or within negative regulation of transcription elongation by RNA polymerase II; positive regulation of cell population proliferation; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human EAPP (E2F associated phosphoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.3), placenta adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eapp in Genome Data Viewer
    Location:
    12 C1; 12 23.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (54717125..54743245, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (54670340..54695899, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene microRNA 1892 Neighboring gene serine palmitoyltransferase, small subunit A Neighboring gene predicted gene, 40884 Neighboring gene predicted gene, 36262 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:55796454-55796563 Neighboring gene STARR-positive B cell enhancer ABC_E2384 Neighboring gene STARR-positive B cell enhancer ABC_E207 Neighboring gene predicted gene, 22513 Neighboring gene ribosomal protein L31, pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic expression analysis of E2F-associated phosphoprotein in stress responses in the mouse. Duan C, et al. Gene, 2016 May 1. PMID 26802973
    2. Spatiotemporal Expression of EAPP Modulates Neuronal Apoptosis and Reactive Astrogliosis After Spinal Cord Injury. Chen M, et al. J Cell Biochem, 2015 Jul. PMID 25704466
    3. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. Novy M, et al. Mol Biol Cell, 2005 May. PMID 15716352, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E2F-associated phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331162.1 → NP_001318091.1  E2F-associated phosphoprotein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC165349, AK012800, CT030142
      Consensus CDS
      CCDS88337.1
      UniProtKB/TrEMBL
      Q3UM97
      Related
      ENSMUSP00000106341.4, ENSMUST00000110713.10

    2. NM_025456.4 → NP_079732.1  E2F-associated phosphoprotein isoform 1

      See identical proteins and their annotated locations for NP_079732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165349, AK007442, CT030142
      Consensus CDS
      CCDS25910.1
      UniProtKB/Swiss-Prot
      Q5BU09, Q9CZB5, Q9D914
      UniProtKB/TrEMBL
      Q3UM97
      Related
      ENSMUSP00000123698.2, ENSMUST00000161592.8
      Conserved Domains (1) summary
      pfam10238
      Location:136 → 279
      Eapp_C; E2F-associated phosphoprotein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      54717125..54743245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516142.5 → XP_006516205.1  E2F-associated phosphoprotein isoform X1

      See identical proteins and their annotated locations for XP_006516205.1

      UniProtKB/Swiss-Prot
      Q5BU09, Q9CZB5, Q9D914
      UniProtKB/TrEMBL
      Q3UM97
      Conserved Domains (1) summary
      pfam10238
      Location:136 → 279
      Eapp_C; E2F-associated phosphoprotein

    2. XM_030246849.2 → XP_030102709.1  E2F-associated phosphoprotein isoform X2

      Conserved Domains (1) summary
      pfam10238
      Location:72 → 215
      Eapp_C; E2F-associated phosphoprotein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BU09.2 GenPept UniProtKB/Swiss-Prot:Q5BU09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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